Books
“Enantioselective Synthesis, Enantiomeric Separations and Chiral Recognition”
Special Issue Editors: Maria Elizabeth Tiritan, Madalena Pinto, Carla Sofia Garcia Fernandes 2020 MDPI•Basel•Beijing•Wuhan•Barcelona•Belgrade•Manchester•Tokyo•Cluj•Tianjin
– “Chemistry of Love and Sex”, Madalena M. M. Pinto, VHCA-Wiley-VCH, 2012 (ISBN-10 3-906390-68-3; ISBN-13 978-3-906390-68-0)
– “Manual de Trabalhos Laboratoriais de Química Orgânica e Farmacêutica”, Madalena M. M. Pinto et col, LIDEL – edições técnicas, Lda., October 2011 (ISBN 978-972-757-750-7)
– Madalena M. M. Pinto, “Química do Amor e do Sexo”, LIDEL – Editors, January 2010 (ISBN 978-972-757-648-7)
Book Chapters
– Maria Elizabeth Tiritan, Madalena Pinto and Carla Fernandes, “Pirkle Type”, Chapter 9, 325-362, in Chiral separations and Stereochemical elucidation – Fundamentals, Methods, and Applications”, editors Quézia Bezerra Cass, Maria Elizabeth Tiritan, João Marcos Batista Júnior, Juliana Cristina Barreiro, John Wiley and Sons, Inc., Hoboken, New Jersey and Canada. Published April 2023.
– Cátia Vilas_Boas, Francisca Carvalhal, Beatriz Pereira, Sílvia Carvalho, Emília Sousa; Madalena M. M. Pinto, Maria José Calhorda, Vítor Vasconcelos, Joana R. Almeida, Elisabeth R. Silva and Marta Correia-da-Silva, “One Step Forward towards the Development of Eco-Friendly Antifouling Coatings: Immobilization od a Sulfated Marine-Inspired Compound”, page 140, Published: March 2021, a printed edition of the Special Issue Sulfur-Containing Marine Bioactives that was published in Marine Drugs, (Ed.) Anna Palumbo
– Agostinho Lemos, Ana Sara Gomes, Joana B. Loureiro, Pedro Brandão, Andreia Palmeira, Madalena M. M. Pinto, Lucília Saraiva and Maria Emília Sousa “Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents” in “Anticancer Agents: Design, Synthesis and Evaluation”, Editor Qiao-Hong Chen California State University USA, 2021, Editorial Office MDPI St. Alban-Anlage 66 4052 Basel, Switzerland
– J.P. Moreira, H. Ramos, S. Salazar, M.M Pinto, L. Saraiva, H. Cidade. “Flavones: Promising Basis for Drug Development of Caspase Activators” chapter 2, Apoptosis, Avid Sciences, Telangana, India, 2017 (http://www.avidscience.com/wp-content/uploads/2017/07/flavones-promising-basis-for-drug-development-of-caspase-activators.pdf).
– Maria Elizabeth Tiritan, Ana Rita Ribeiro, Carla Fernandes and Madalena M. M. Pinto, “Chiral pharmaceuticals”, Kirk-Othmer Encyclopedia of Chemical Technology, 1-28, Published Online: 15 SEP 2016, DOI: 10.1002/0471238961.1608011823092009.a01.pub2
– Fernandes, H. Cidade, S. Cravo, E. Sousa, M. Pinto Chapter1. Separation and Purification of Mixtures: 1.12. “Analysis of racemic and (S)-ibuprofen”, in Comprehensive Organic Chemistry Experiments for the Laboratory Classroom Royal Society of Chemistry (COCEL), Editors: Carlos A M Afonso, Nuno R Candeias, Dulce Pereira Simão, Alexandre F Trindade, Jaime A S Coelho, Bin Tan, Robert Franzén, Print publication date: 16 Dec 2016 Copyright: 2017 Print ISBN: 978-1-84973-963-4
– E. Sousa, S. Cravo, C. Fernandes, M. Pinto, Separation and Purification of Mixtures: 1.13. “Determining partition coefficients of sulfonamides by reversed-phase chromatography”, in Comprehensive Organic Chemistry Experiments for the Laboratory Classroom Royal Society of Chemistry (COCEL), Editors: Carlos A M Afonso, Nuno R Candeias, Dulce Pereira Simão, Alexandre F Trindade, Jaime A S Coelho, Bin Tan, Robert Franzén, Print publication date: 16 Dec 2016 Copyright: 2017 Print ISBN: 978-1-84973-963-4
– M.M.M. Pinto (invited author), Raquel A. P. Castanheiro and Anake Kijjoa (2014), “ Xanthones from Marine-Derived Microorganisms: Isolation, Structure Elucidation” in Handbook of Chemical and Biological Plant, edited by Kurt Hostettmann, Shilin Chen, Andrew Marston and Hermann Stuppner. Chichester, UK: John Wiley & Sons, Ltd, pp 611-632
– A. Palmeira, F. Rodrigues, E. Sousa, M. Pinto, M. H. Vasconcelos, M. X. Fernandes, “Pharmacophore-based screening as a clue for the discovery of new P-glycoprotein inhibitors”, Ed. M. P. Rocha et al., IWPACBB, AISC74, Advances in Intelligent and Soft Computing, 2010, 175-180.
– E. V. Costa, M. E. Sousa, J. Rocha, C. A. Montanari, M. M. Pinto, “Structure Based Design of Potential Inhibitors of Steroid Sulfatase”, Ed. M. P. Rocha et al., IWPACBB, AISC74, Advances in Intelligent and Soft Computing, 2010, 151-156.
– Natural Products: Chemistry, Biochemistry and Pharmacology”, NAROSA PUBLISHING HOUSE PVT. LTD., NEW DELHI, INDIA (www.narosa.com), ALPHASCIENCE INTERNATIONAL, OXFORD, UK (www.alphasci.com), ISBN: 978-81-7319-886-1, 2009
Chapter 11: Natural Prenylated Xanthones: Chemistry and Biological Activities, Madalena M. M. Pinto (invited author) and Raquel Castanheiro.
Chapter 14: Sulfated Flavonoids: Nature Playing with the Hydrophilic-Hydrophobic Balance, Maria Emilia Sousa, Marta Correia da Silva, and Madalena M.M. Pinto.
– Sousa, M. E., Correia-da-Silva, M., Pinto, M. M. M., “Sulfated Flavonoids: Nature Playing with the Hydrophilic-Hydrophobic Balance” In Natural Products: Chemistry, Biochemistry and Pharmacology, 1st ed.; Brahmachari, G., Eds.; Narosa Publishing House: New Delhi, India, 2008; pp 392-416.
– Madalena M. M. Pinto, Honorina M. M. Cidade, “Inclusion complex of Diazepam with Cyclodextrins in Solid Phase” in IUPAC: Practical Studies for Medicinal Chemistry – An integrating approach for developing countries, 2006, Eds Antonio Monge and C. Robin Ganelli, Chapter I , Exercise I.8. (http://www.iupac.org/publications/cd/medicinal_chemistry/index.html)
– Honorina Cidade, Madalena Pinto, “Analysis of Racemic Ibuprofen and (S) – Ibuprofen for the Formation of Diasterioisomeric Derivatives” in IUPAC: Practical Studies for Medicinal Chemistry – An integrating approach for developing countries, 2006, Eds Antonio Monge and C. Robin Ganelli, Chapter I.10. (http://www.iupac.org/publications/cd/medicinal_chemistry/index.html)
– Madalena M.M. Pinto, Anake Kijjoa. “Macromoléculas e Metabolitos Secundários como Indicadores de Evolução”. Em: A Evolução Cósmica e a Origem da Vida, 1985, Ed. Hernâni L. S. Maia e Joaquim J. Moura Ramos, Livraria Almedina, Coimbra.
Patents/Scientific Papers
Patents
7 – Patente Internacional N.º: PCT/IB2020/057831, prioridades: PT 115744 “Pyrazino [1,2-b]quinazoline-3,6-diones derivatives, their production uses thereof”, Maria Emilia da Silva Pereira de Sousa, Solida Long, Madalena Maria de Magalhães Pinto, Diana Resende, Anake Kijjoa, Paulo Manuel Rodrigues Martins da Costa, Joana Manuela Machado Freitas da Silva, Fatima Nogueira. (P797.5 PP Data de Depósito: 20.08.2020).
6- Patente Internacional PCT/IB2019/059886, “Xanthonic compounds and their use as antifouling agents”, Marta Correia da Silva, Madalena Pinto, Emília Sousa, Vitor Vasconcelos, Joana Reis de Almeida, Elisabete Geraldes, CIIMAR – Centro Interdisciplinar de Investigação Marinha e Ambiental. (depósito 18/11/2019).
5- Patente Portuguesa nº P797.5 PP, “Pyrazino [1,2-b]quinazoline-3,6-diones derivatives, their production uses thereof”, Maria Emilia da Silva Pereira de Sousa, Solida Long, Madalena Maria de Magalhães Pinto, Diana Resende, Anake Kijjoa, Paulo Manuel Rodrigues Martins da Costa, Joana Manuela Machado Freitas da Silva, Fátima Nogueira. (P797.5 PP Data de Depósito: 20.08.2019).
4- Patente Portuguesa nº NPAT325’18, “Oxygenated xanthone derivatives as antifouling agents”, Marta Correia da Silva, Madalena Pinto, Emília Sousa, Vitor Vasconcelos, Joana Reis de Almeida, Elisabete Geraldes. (PPP 61236 depósito 17/12/2018).
3-Patente Internacional WO 2013/105037, “Inhibitors of p53-MDM2 interaction”, Madalena Pinto, Lucília Saraiva, Emília Sousa, Alberto Inga, Mariana Leão, Ana Paiva, Clara Pereira. (Publicação 2013/07/18)
2- Patente Portuguesa nº 104739, “Xantonas sulfatadas e análogos xantónicos glicosilados sulfatados com actividade anticoagulante e processos para a sua preparação”, Madalena Pinto, Maria Emília Sousa, Marta Correia da Silva, Franklim Marques, Félix Carvalho. (Publicação no Boletim da Propriedade Industrial nº 47/2011, 09/03/2011)
1- M. Pinto, M. E. Tiritan, C. Fernandes, Q. Cass, Portuguese Patent nº 104679: “Fases Estacionárias Quirais baseadas em Derivados Xantónicos“. (Publication in Boletim da Propriedade Industrial nº 15/2011, 21-01-2011)
Scientific Papers
(last 10 years)
Published
– Joana Moreira, Joana B. Loureiro, Danilo Correia, Andreia Palmeira, Madalena M. Pinto, Lucília Saraiva and Honorina Cidade, Structure–Activity Relationship Studies of Chalcones and Diarylpentanoids with Antitumor Activity: Potency and Selectivity Optimization, Pharmaceuticals 2023, 16, 1354
– Sara F. Vieira, Joana Araújo, Virgínia M. F. Gonçalves, Carla Fernandes, Madalena Pinto, Helena Ferreira, Nuno M. Neves, Maria Elizabeth Tiritan, Synthesis and Anti-Inflammatory Evaluation of a Library of Chiral Derivatives of Xanthones Conjugated with Proteinogenic Amino Acids, Int. J. Mol. Sci. 2023, 24, 10357.
– Joana Moreira, Patrícia M. A. Silva, Matilde Barros, Lucília Saraiva, Madalena Pinto, Hassan Bousbaa, Honorina Cidade, Discovery of a New Chalcone-Trimethoxycinnamide Hybrid with Antimitotic Effect: Design, Synthesis, and Structure—Activity Relationship Studies, Pharmaceuticals 2023, 16, 879.
– Mariana C. Almeida, Nikoletta Szemerédi, Fernando Durães, Solida Long, Diana I. S. P. Resende, Paulo Martins da Costa, Madalena Pinto, Gabriella Spengler, Emília Sousa, Effect of Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones in the Virulence of Resistant Bacteria, Antibiotics 2023, 12, 922.
– José X. Soares, Inês Afonso, Adaleta Omerbasic, Daniela R. P. Loureiro, Madalena M. M. Pinto, Carlos M. M. Afonso, The Chemical Space of Marine Antibacterials: Diphenyl Ethers, Benzophenones, Xanthones, and Anthraquinones. Molecules 2023, 28, 4073.
– Cátia Vilas‑Boas, Elisabete R. Silva, Diana Resende, Beatriz Pereira, Gonçalo Sousa, Madalena Pinto, Joana R. Almeida, Marta Correia‑da‑Silva, Emília Sousa, 3,4‑Dioxygenated xanthones as antifouling additives for marine coatings: in silico studies, seawater solubility, degradability, leaching, and antifouling performance, Environmental Science and Pollution Research, published on line: 02 May 2023, https://doi.org/10.1007/s11356-023-26899-1
– Ana J. Coutinho, Marina Pinheiro, Ana R. Neves and Madalena M.M. Pinto, Therapeutic Potential of Genistein: Preclinical Studies, Clinical Evidence, and Nanotechnology Application, Current Medicinal Chemistry, 2023, 30, 2480-2517
– Bruno Horta, Joana Freitas-Silva, Jani Silva, Francisca Dias, Ana Luísa Teixeira, Rui Medeiros, Honorina Cidade, Madalena Pinto, Fátima Cerqueira, Antitumor Effect of Chalcone Derivatives against Human Prostate (LNCaP and PC-3), Cervix HPV-Positive (HeLa) and Lymphocyte (Jurkat) Cell Lines and Their Effect on Macrophage Functions. Molecules 2023, 28, 2159.
– Carla Fernandes, Ricardo Ribeiro, Madalena Pinto, Anake Kijjoa, Absolute Stereochemistry Determination of Bioactive Marine-Derived Cyclopeptides by Liquid Chromatography Methods: An Update Review (2018–2022). Molecules 2023, 28, 615.
– Miguel Maia, Fernando Durães, Diana I. S. P. Resende, Nikoletta Szemerédi, Luís Gales, Paulo Martins-da-Costa, Madalena Pinto, Gabriella Spengler, Emília Sousa. Xanthene Derivatives Targeting Bacterial Efflux Pumps, Quorum-Sensing, and Biofilm Formation. Drugs Drug Candidates 2022, 1, 29–42.
– Daniela Pereira, Fernando Durães, Nikoletta Szemerédi, Joana Freitas-da-Silva, Eugénia Pinto, Paulo Martins-da-Costa, Madalena Pinto, Marta Correia-da-Silva, Gabriella Spengler, Emília Sousa, Honorina Cidade, New Chalcone–Triazole Hybrids with Promising Antimicrobial Activity in Multidrug Resistance Strains, Int. J. Mol. Sci. 2022, 23, 14291.
– Marialucia Gallorini, Simone Carradori, Diana I. S. P. Resende, Luciano Saso, Alessia Ricci, Andreia Palmeira, Amelia Cataldi, Madalena Pinto, Emília Sousa, Natural and Synthetic Xanthone Derivatives Counteract Oxidative Stress via Nrf2 Modulation in Inflamed Human Macrophages. Int. J. Mol. Sci. 2022, 23, 13319.
– Joana Cardoso, Joana Freitas‐Silva, Fernando Durães, Diogo Teixeira Carvalho, Luís Gales, Madalena Pinto, Emília Sousa, Eugénia Pinto. Antifungal Activity of a Library of Aminothioxanthones. Antibiotics 2022, 11, 1488.
– Carla Fernandes, Rita Lima, Madalena M. M. Pinto, Maria Elizabeth Tiritan, Chromatographic supports for enantioselective liquid chromatography: Evolution and innovative trends, Journal of Chromatography A, 2022, 1684, 463555.
– Joana Moreira, Lucilia Saraiva, Madalena M. Pinto, Honorina Cidade, Bioactive Diarylpentanoids: Insights into the Biological Effects beyond Antitumor Activity and Structure–Activity Relationships, Molecules 2022, 27, 6340.
– Cátia Vilas-Boas, Virgínia Gonçalves, Paolo De Marco, Emília Sousa, Madalena Pinto, Elisabete R. Silva, Maria Elizabeth Tiritan, Marta Correia-da-Silva, Quantification of a Sulfated Marine-Inspired Antifouling Compound in Several Aqueous Matrices: Biodegradation Studies and Leaching Assays from Polydimethylsiloxane Coatings. Mar. Drugs 2022, 20, 548.
– José X. Soares, Álvaro Santos, Carla Fernandes, Madalena M. M. Pinto, Liquid Chromatography on the Different Methods for the Determination of Lipophilicity: An Essential Analytical Tool in Medicinal Chemistry, Chemosensors 2022, 10, 340
– Ana R. Neves, Luciana C. Gomes, Sara I. Faria, João Sousa, Raquel Ruivo, Inês Páscoa, Madalena Pinto, Emília Sousa, Miguel M. Santos, Elisabete R. Silva, Marta Correia-da-Silva, Filipe Mergulhão, Antifouling Marine Coatings with a Potentially Safer and Sustainable Synthetic Polyphenolic Derivative, Mar. Drugs 2022, 20, 507
– A. S. Gomes, A. Correia, A. Rahikkala, E. Mäkilä, M. M. Pinto, E. Sousa, J. Salonen, L. Saraiva, H. A. Santos, Folic acid-mesoporous silicon nanoparticles enhance the anticancer activity of the p73-activating small molecule LEM2, International Journal of Pharmaceutics, 2022, 624, 121959.
– Rita Lima, Carla Fernandes, Madalena M. M. Pinto, Molecular modifications, biological activities, and applications of chitosan and derivatives: A recent update. Chirality 2022;34:1166–1190
– Ana Rita Neves, Cátia Vilas Boas, Catarina Gonçalves, Vítor Vasconcelos, Madalena Pinto, Elisabete R. Silva, Emília Sousa, Joana R. Almeida b, Marta Correia-da-Silva, Gallic acid derivatives as inhibitors of mussel (Mytilus galloprovincialis) larval settlement: Lead optimization, biological evaluation and use in antifouling coatings. Bioorganic Chemistry 2022,126, 105911,
– Ana Jesus, Fernando Durães, Nikoletta Szemerédi, Joana Freitas-Silva, Paulo Martins da Costa, Eugénia Pinto, Madalena Pinto, Gabriella Spengler, Emília Sousa and Honorina Cidade, BDDE-Inspired Chalcone Derivatives to Fight Bacterial and Fungal Infections, Mar. Drugs 2022, 20, 315.
– Joana Moreira, Fernando Durães, Joana Freitas-Silva, Nikoletta Szemeredi, Diana I.S.P. Resende, Eugenia Pinto, Paulo Martins da Costa, Madalena Pinto, Gabriella Spengler, Honorina Cidade, Emília Sousa, New diarylpentanoids and chalcones as potential antimicrobial adjuvants. Bioorg. Med. Chem. Lett. 2022, 67, 128743
– Daniela Pereira, Madalena Pinto, Marta Correia-da-Silva and Honorina Cidade. Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry. Molecules 2022, 27, 230
– José X. Soares, Daniela R. P. Loureiro, Ana Laura Dias, Salete Reis, Madalena M. M. Pinto and Carlos M. M. Afonso. Bioactive Marine Xanthones: A Review. Mar. Drugs 2022, 20, 58.
– Cláudia Pinto, Honorina Cidade, Madalena Pinto and Maria Elizabeth Tiritan, Chiral Flavonoids as Antitumor Agents, Pharmaceuticals 2021, 14(12), 1267
– Ana Rita Neves, Daniela Pereira, Catarina Gonçalves, Joana Cardoso, Eugénia Pinto, Vítor Vasconcelos, Madalena Pinto, Emília Sousa, Joana R. Almeida, Honorina Cidade and Marta Correia‐da‐Silva, Natural Benzo/Acetophenones as Leads for New Synthetic Acetophenone Hybrids Containing a 1,2,3‐Triazole Ring as Potential Antifouling Agents, Mar. Drugs 2021, 19, 682.
– Pedro Novais, Patrícia M. A. Silva, Joana Moreira, Andreia Palmeira, Isabel Amorim, Madalena Pinto, Honorina Cidade and Hassan Bousbaa. BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity. Molecules 2021, 26, 7139.
– Fernando Durães, Sara Cravo, Joana Freitas-Silva, Nikoletta Szemerédi, Paulo Martins-da-Costa, Eugénia Pinto, Maria Elizabeth Tiritan, Gabriella Spengler, Carla Fernandes, Emília Sousa and Madalena Pinto, Enantioselectivity of Chiral Derivatives of Xanthones in Virulence Effects of Resistant Bacteria. Pharmaceuticals 2021, 14, 1141.
– Diana I. S. P. Resende, Joana R. Almeida, Sandra Pereira, Alexandre Campos, Agostinho Lemos, Jeffrey E. Plowman, Ancy Thomas, Stefan Clerens, Vitor Vasconcelos, Madalena Pinto, Marta Correia-da-Silva and Emília Sousa, From Natural Xanthones to Synthetic C-1 Aminated 3,4-Dioxygenated Xanthones as Optimized Antifouling Agents, Mar. Drugs 2021, 19, 638.
– Catia Vilas-Boas, Ana Rita Neves, Francisca Carvalhal, Sandra Pereira, Maria José Calhorda, Vitor Vasconcelos, Madalena Pinto, Emília Sousa, Joana R. Almeida, Elisabete R. Silva, Marta Correia-da-Silva, Multidimensional characterization of a new antifouling xanthone: Structure-activity relationship, environmental compatibility, and immobilization in marine coatings, Ecotoxicology and Environmental Safety, 2021, 228, 112970
– Fernandes, C.; Teixeira, J.; Pinto, M.M.M.; Tiritan, M.E. Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods. Molecules 2021, 26, 5477.
– Durães, F.; Szemerédi, N.; Kumla, D.; Pinto, M.; Kijjoa, A.; Spengler, G.; Sousa, E. Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants. Mar. Drugs 2021, 19, 475.
– Long, S.; Furlani, I.L.; de Oliveira, J.M.; Resende, D.I.S.P.; Silva, A.M.S.; Gales, L.; Pereira, J.A.; Kijjoa, A.; Cass, Q.B.; Oliveira, R.V.; Sousa, E.; Pinto, M.M.M. Determination of the Absolute, Configuration of Bioactive Indole‐Containing Pyrazino[2,1‐b]quinazoline‐3,6‐Diones and Study of Their In Vitro Metabolic Profile. Molecules 2021, 26, 5070.
– M.C. Almeida, D.I.S.P. Resende, P.M. da Costa, M.M.M. Pinto, E. Sousa, Tryptophan derived natural marine alkaloids and synthetic derivatives as promising antimicrobial agents, European Journal of Medicinal Chemistry, 2021, 209, 112945-112978.
– M. Maia, D.I.S.P. Resende, F. Durães, M.M.M. Pinto, E. Sousa, Xanthenes in Medicinal Chemistry – Synthetic strategies and biological activities, European Journal of Medicinal Chemistry, 2021, 210, 113085-113114.
– Joana Moreira, Joana Almeida, Joana B. Loureiro, Helena Ramos, Andreia Palmeira, Madalena M.M. Pinto, Lucília Saraiva, and Honorina Cidade, A new diarylpentanoid with potential activation of the p53 pathway: combination of in silico screening studies, synthesis, and biological activity evaluation, ChemMedChem. 2021, 10.1002/cmdc.202100337.
– Joana Moreira, Joana Almeida, Lucília Saraiva, Honorina Cidade and Madalena Pinto, Chalcones as Promising Antitumor Agents by Targeting the p53 Pathway: An Overview and New Insights in Drug-Likeness. Molecules 2021, 26, 3737.
– Rui Medeiros, Joana Freitas-Silva, Jani Silva, Francisca Dias, Emília Sousa, Madalena Pinto and Fátima Cerqueira, Effect of 1-Carbaldehyde-3,4-dimethoxyxanthone on Prostate and HPV-18 Positive Cervical Cancer Cell Lines and on Human THP-1 Macrophages. Molecules 2021, 26, 3721.
– Fernando Durães, Andreia Palmeira, Bárbara Cruz, Joana Freitas-Silva, Nikoletta Szemerédi, Luís Gales, Paulo Martins da Costa, Fernando Remião, Renata Silva, Madalena Pinto, Gabriella Spengler and Emília Sousa. Antimicrobial Activity of a Library of Thioxanthones and Their Potential as Efflux Pump Inhibitors. Pharmaceuticals 2021, 14, 572.
– Thierno Moussa Ndongo, Marieta L. C. Passos, Fernando Durães, Diana I. S. P. Resende, Madalena Pinto, Emília Sousa, Maria Lúcia M. F. S. Saraiva, Microsequential injection analysis/lab‐on‐valve system for the automatic evaluation of acetylcholinesterase inhibitors, Arch Pharm. 2021; e2100150, 1-11.
– Mendanha, D.; Vieira de Castro, J.; Moreira, J.; Costa, B.M.;Cidade, H.; Pinto, M.; Ferreira, H.; Neves, N.M. A New Chalcone Derivative with Promising Antiproliferative and Anti-Invasion Activities in Glioblastoma Cells. Molecules 2021, 26, 3383.
– Durães, F.; Silva, P.M.A.; Novais, P.; Amorim, I.; Gales, L.; Esteves, C.I.C.; Guieu, S.; Bousbaa, H.; Pinto, M.; Sousa, E. Tetracyclic Thioxanthene Derivatives: Studies on Fluorescence and Antitumor Activity. Molecules 2021, 26, 3315.
– Fernando Durães, Diana I. S. P. Resende, Andreia Palmeira, Nikoletta Szemerédi,Madalena M. M. Pinto, Gabriella Spengler and Emília Sousa, Xanthones Active against Multidrug Resistance and Virulence Mechanisms of Bacteria, Antibiotics 2021, 10, 600
– Daniela R. P. Loureiro, José X. Soares, Ana Maia, André M. N. Silva, Maria Rangel, Carlos M. G. Azevedo, Steffen V. Hansen, Trond Ulven, Madalena M. M. Pinto, Salette Reis, and Carlos M. M. Afonso, One-Pot Synthesis of Xanthone by Carbonylative Suzuki Coupling Reaction, ChemistrySelect 2021, 6, 4511-4514
– Ana Alves, Paulo Costa, Madalena Pinto, Domingos Ferreira and Marta Correia‐da‐Silva, Small Molecules of Marine Origin as Potential Anti‐Glioma Agents. Molecules 2021, 26, 2707
– Madalena M. M. Pinto, Andreia Palmeira, Carla Fernandes, Diana I. S. P. Resende, Emília Sousa, Honorina Cidade, Maria Elizabeth Tiritan, Marta Correia-da-Silva and Sara Cravo, From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones. Molecules 2021, 26, 431.
– Phyo YZ, Teixeira J, Gonçalves R, Palmeira A, Tiritan MA, Bousbaa H, Pinto MMM, Fernandes C, Kijjoa A, Chiral derivatives of xanthones and benzophenones: Synthesis, enantioseparation, molecular docking, and tumor cell growth inhibition studies. Chirality. 2021;33:153-166
– Daniela Pereira, Catarina Gonçalves, Beatriz T. Martins, Andreia Palmeira, Vitor Vasconcelos, Madalena Pinto, Joana R. Almeida, Marta Correia-da-Silva and Honorina Cidade, Flavonoid Glycosides with a Triazole Moiety for Marine Antifouling Applications: Synthesis and Biological Activity Evaluation. Mar. Drugs 2021, 19, 5
– Long, S.; Loureiro, J.B.; Carvalho, C.; Gales, L.; Saraiva, L.; Pinto, M.M.M.; Puthongking, P.; Sousa, E. Semi-Synthesis of Small Molecules of Aminocarbazoles: Tumor Growth Inhibition and Potential Impact on p53. Molecules 2021, 26, 1637
– G.P. Rosa, A. Palmeira, D.I.S.P. Resende, I.F. Almeida, A. Kane-Pagès, M. C. Barreto, E. Sousa, M.M.M. Pinto, Xanthones for melanogenesis inhibition: Molecular docking and QSAR studies to understand their anti-tyrosinase activity. Bioorg. Med. Chem. 2021, 29, 115873
– Pereira, D.; Gonçalves, C.; Martins, B.T.; Palmeira, A.; Vasconcelos, V.; Pinto. M.; Almeida, J.R.; Correia-da-Silva, M.; Cidade, H. Flavonoid Glycosides with a Triazole Moiety for Marine Antifouling Applications: Synthesis and Biological Activity Evaluation. Mar. Drugs 2021, 19, 5
– Tiritan, M.E.; Pinto, M.; Fernandes, C. Enantioselective Synthesis, Enantiomeric Separations and Chiral Recognition, Molecules 2020, 25(7), 1713
– Martins, M.; Silva, R.; Pinto, M.; Sousa, E. Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer’s Disease. Pharmaceuticals 2020, 13(9), 242
– Malta, R., Loureiro, J.B.; Costa, P.; Sousa, E.; Pinto, M.; Saraiva, L.; Amaral, M.H. Development of lipid nanoparticles containing the xanthone LEM2 for topical treatment of melanoma, Journal of Drug Delivery Science and Technology, 2020, 102226.
– Maria L. Carraro, Sandra Marques, Ana Sofia Silva, Bruno Freitas, Patrícia M. A. Silva, Joel Pedrosa, Paolo De Marco, Hassan Bousbaa, Carla Fernandes, Maria Elizabeth Tiritan, Artur M. S. Silva, and Madalena M. M. Pinto, Synthesis of new chiral derivatives of xanthones with enantioselective effect on tumor cell growth and DNA crosslinking, ChemistrySelect 2020, 5,10285 – 10291
– Cátia Vilas-Boas, Francisca Carvalhal, Beatriz Pereira, Sílvia Carvalho, Emília Sousa, Madalena M. M. Pinto, Maria José Calhorda, Vitor Vasconcelos, Joana R. Almeida, Elisabete R. Silva, and Marta Correia-da-Silva, One Step Forward towards the Development of Eco-Friendly Antifouling Coatings: Immobilization of a Sulfated Marine-Inspired Compound, Mar. Drugs 2020, 18, 489.
– Mariana Silva, Lucília Saraiva, Madalena Pinto and Maria Emília Sousa, Boronic Acids and their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications, Molecules, 2020, 25, 4323; (Medicinal Chemistry, Special Issue “Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes 2020”)
– Márcia Martins, Renata Silva, Madalena Pinto, Emília Sousa, Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer’s Disease, Pharmaceuticals, 2020, 13, 242
– S. Long; D. Resende; A. Kijjoa; A. Silva; M. E. Tiritan; P. Pereira-Terra; J. Freitas Silva; S. Barreiro; R. Silva; F. Remião; E. Pinto; P. Costa; M. E. Sousa; M. Pinto. New Marine-Derived Indolymethyl Pyrazinoquinazoline Alkaloids with Promising Antimicrobial Profiles. RSC Advances, 2020, 10, 31187 – 31204
– Diana I. S. P. Resende, Fernando Durães, Miguel Maia, Emília Sousa and Madalena M. M. Pinto, Recent advances in the synthesis of xanthones and azaxanthones, Org. Chem. Front. 2020 DOI: 10.1039/D0QO00659A
– Joana R. Almeida, Andreia Palmeira, Alexandre Campos, Isabel Cunha, Micaela Freitas, Aldo Barreiro Felpet, Maria V. Turkina, Vitor Vasconcelos, Madalena Pinto, Marta Correia-da-Silva and Emília Sousa, Structure-Antifouling Activity Relationship and Molecular Targets of Bio-Inspired(thio)xanthones, Biomolecules 2020, 10, 1126
-Filipa Barbosa, Eugénia Pinto, Anake Kijjoa, Madalena Pinto, Emília Sousa, Targeting antimicrobial drug resistance with marine natural products, International Journal of Antimicrobial Agents, 2020, 56(1), 106005
– Andreia Palmeira, Emília Sousa, Aylin Kepler, Ramazan Sabirli, Tarık Gören, Ibrahim Türkçüer, Özgür Kurt, Madalena M. Pinto and M. Helena Vasconcelos, Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection, Pharmaceuticals 2020, 13, 132; doi:10.3390/ph13060132 (Communication)
– Diana I. S. P. Resende, Mariana C. Almeida, Bruna Maciel, Helena Carmo, José Sousa Lobo, Carlotta Dal Pozzo, Sara M. Cravo, Gonçalo P. Rosa, Aida Kane-Pagès, Maria do Carmo Barreto, Isabel F Almeida, Maria Emília de Sousa and Madalena M. M. Pinto, Efficacy, Stability, and Safety Evaluation of New Polyphenolic Xanthones Towards Identification of Bioactive Compounds to Fight Skin Photoaging, Molecules 2020, 25, 2782
– Ana Alves, Emília Sousa, Anake Kijjoa and Madalena Pinto, Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics, Molecules 2020, 25, 2536
– Diana I. S. P. Resende, Patrícia Pereira-Terra, Joana Moreira, Joana Freitas-Silva, Agostinho Lemos , Luís Gales, Eugénia Pinto, Maria Emília de Sousa, Paulo Martins da Costa and Madalena M. M. Pinto, Synthesis of a Small Library of Nature-Inspired Xanthones and Study of Their Antimicrobial Activity, Molecules 2020, 25, 2405
– F. Barbosa, E. Pinto, A. Kijjoa, M. Pinto, E. Sousa. Targeting Antimicrobial Drug Resistance with Marine Natural Products. International Journal of Antimicrobial Agents, 2020, 56(1), 106005
– Diana I. S. P. Resende, Patrícia Pereira-Terra, Joana Moreira, Joana Freitas-Silva, Agostinho Lemos, Luís Gales, Eugénia Pinto, Maria Emília de Sousa, Paulo Martins da Costa and Madalena M. M. Pinto, Synthesis of a Small Library of Nature-Inspired Xanthones and Study of Their Antimicrobial Activity, Molecules 2020, 25, 2405
– Madalena M.M. Pinto, Carla Fernandes and Maria E. Tiritan,, Chiral Separations in Preparative Scale: A Medicinal Chemistry Point of View, Molecules 2020, 25, 1931
– H. Cidade, V. Rocha, A. Palmeira, C. Marques, M. E. Tiritan, H. Ferreira, J. S. Lobo, I. F. Almeida, M. E. Sousa, M. Pinto, In silico and in vitro antioxidant and cytotoxicity evaluation of oxygenated xanthone derivatives, Arabian Journal of Chemistry, 2020,13, 17-26
– Joana Macedo, Lucília Saraiva, Madalena M. Pinto, Honorina Cidade, Diarylpentanoids with antitumor activity: A critical review of structure-activity relationship studies, Europena Journal of Medicinal Chemistry, 2020, 192, 112177
– Daniela R. P. Loureiro, Álvaro F. Magalhães, José X. Soares, Joana Pinto, Carlos M. G. Azevedo, Sara Vieira, Ana Henriques, Helena Ferreira, Nuno Neves, Hassan Bousbaa, Salette Reis, Carlos M. M. Afonso, and Madalena M. M. Pinto. Yicathins B and C and Analogues: Total Synthesis, Lipophilicity and Biological Activities, ChemMedChem 2020, 15, 1–8
– Pedro Brandão, Joana Moreira, Joana Almeida, Nair Nazareth, Ivo E. Sampaio-Dias, Vitor Vasconcelos, Rosário Martins, Pedro Leão, Madalena Pinto, Lucília Saraíva,and Honorina Cidade, Norhierridin B, a New Hierridin B-Based Hydroquinone with Improved Antiproliferative Activity, Molecules 2020, 25, 1578
– H. Cidade, V. Rocha, A. Palmeira, C. Marques, M. E. Tiritan, H. Ferreira, J. S. Lobo, I. F. Almeida, M. E. Sousa, M. Pinto. In silico and in vitro antioxidant and cytotoxicity evaluation of oxygenated xanthone derivatives, Arabian Journal of Chemistry 2020, 13, 17-26
– A. R. Neves, J. R. Almeida, F. Carvalhal, A. Câmara, S. Pereira, J. Antunes, V. Vasconcelos, M. Pinto, E. R. Silva, E. Sousa, M. Correia-da-Silva. Overcoming environmental problems of biocides: synthetic bile acid derivatives as a sustainable alternative. Ecotoxicology and Environmental Safety 2020, 187, 109812.
H. Cidade, V. Rocha, A. Palmeira, C. Marques, M. E. Tiritan, H. Ferreira, J. S. Lobo, I. F. Almeida, M. E. Sousa, M. Pinto. In silico and in vitro antioxidant and cytotoxicity evaluation of oxygenated xanthone derivatives, Arabian Journal of Chemistry 2020, 13, 17-26
– D. Pereira, R. T. Lima, A. Palmeira, H. Seca, J. Soares, S. Gomes, L. Raimundo, C. Maciel, M. Pinto, E. Sousa, M. Helena Vasconcelos, L. Saraiva, H. Cidade. Design and synthesis of new inhibitors of p53- MDM2 interaction with a chalcone scaffold. Arabian Journal of Chemistry 2019, 12, 4150-4161
– Long, S.; Resende, D. I. S. P.; Kijjoa, A.; Silva, A. M. S.; Fernandes, R.; Xavier, C. P. R.; Vasconcelos, M. H.; Sousa, E.; Pinto, M. M. M. Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects. Molecules 2019,24, 534
– Ye‛ Zaw Phyo, Joana Teixeira, Maria Elizabeth Tiritan, Sara Cravo, Andreia Palmeira, Luís Gales, Artur M.S. Silva, Madalena M.M. Pinto, Anake Kijjoa, Carla. New chiral stationary phases for liquid chromatography based on small molecules: development, enantioresolution evaluation and chiral recognition mechanisms. Chirality, 2019, 81-97
– Patricia Pinto, Carmen Mariana Machado, Joana Moreira, José Diogo P. Almeida, Patrícia M.A. Silva, Ana C. Henriques, José X. Soares, Jorge A.R. Salvador, Carlos Afonso, Madalena Pinto, Hassan Bousbaa, Honorina Cidade, Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor activity and lipophilicity, European Journal of Medicinal Chemistry, 2019, 184, 111752, 1-14
– Maribel T, Pedro M, Nascimento MSJ, Pinto MMM, Barbosa CM, Development and characterization of PLGA nanoparticles containing 1,3-dihydroxy-2-methylxanthone with improved antitumor activity on a human breast cancer cell line, Pharm Dev Technol. 2019 Jul 4:1-36. doi: 10.1080/10837450.2019.1638398. [Epub ahead of print 29 July]
– João P do Carmo, Ye Zaw Phyo, Andreia Palmeira1, Maria Elizabeth Tiritan, Carlos Afonso, Anake Kijjoa, Madalena M M Pinto, Carla Fernandes, Enantioseparation, recognition mechanisms and binding of xanthones on human sérum albumin by liquid chromatography, Bioanalysis 2019 Jul 12. doi: 10.4155/bio-2019-0074. [Epub ahead of print]
– Ana J. S. Alves, José A. Pereira, Tida Dethoup, Sara Cravo, Sharad Mistry, Artur M. S. Silva, Madalena M. M. Pinto and Anake Kijjoa, A New Meroterpene, A New Benzofuran Derivative and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Acremonium persicinum KUFA 1007 and Their Anticholinesterase Activities, Mar. Drugs 2019, 17, 379
– S Silva, M Ferreira, AS Oliveira, C Magalhães, ME Sousa, M Pinto, J M Sousa Lobo, I F Almeida, Evolution of the use of antioxidants in anti‐aging cosmetics, International Journal of Cosmetic Science, 2019, 41, 378–386
– Viviana Silva, Fátima Cerqueira, Nair Nazareth, Rui Medeiros, Amélia Sarmento ,Emília Sousa and Madalena Pinto, 1,2-Dihydroxyxanthone: Effect on A375-C5 Melanoma Cell Growth Associated with Interference with THP-1 Human Macrophage Activity, Pharmaceuticals 2019, 12, 85
– Agostinho Lemos, Ana Sara Gomes, Joana B. Loureiro, Pedro Brandão, Andreia Palmeira, Madalena M. M. Pinto, Lucília Saraiva and Maria Emília Sousa, Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents, Molecules 2019, 24, 1975
– Francisca Carvalhal, Ricardo R. Cristelo, Diana I. S. P. Resende, Madalena M. M. Pinto, Emília Sousa, and Marta Correia-da-Silva, Antithrombotics from the Sea: Polysaccharides and Beyond, Mar. Drugs 2019, 17, 170
– Joana Teixeira, Maria Elizabeth Tiritan, Madalena M. M. Pinto and Carla Fernandes, Chiral Stationary Phases for Liquid Chromatography:Recent Developments, Molecules 2019, 24, 865
– Carla Fernandes, Maria Letícia Carraro, João Ribeiro, Joana Araújo, Maria Elizabeth Tiritan, and Madalena M. M. Pinto, Synthetic Chiral Derivatives of Xanthones: Biological Activities and Enantioselectivity Studies, Molecules 2019, 24, 791;
– Diana I. S. P. Resende, Papichaya Boonpothong, Emília Sousa, Anake Kijjoa and Madalena M. M. Pinto, Chemistry of the fumiquinazolines and structurally, related alkaloids, Nat. Prod. Rep., 2019, 36, 7–34
– Sara Gomes, Liliana Raimundo, Joana Soares, Joana B. Loureiro, Mariana Leão, Helena Ramos, Madalena N. Monteiro, Agostinho Lemos, Joana Moreira, Madalena Pinto, Petr Chlapek, Renata Veselska, Emília Sousa, Lucília Saraiva; New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma. Cancer Letters, 2019, 446, 90–102
– Alves, A.; Correia-da-Silva, M.; Nunes, C.; Campos, J.; Sousa, E.; Silva, P.M.A.; Bousbaa, H.; Rodrigues, F.; Ferreira, D.; Costa, P.C.; Pinto, M. Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations. Molecules 2019, 24, 409
– Ana Jesus, Marta Correia-da-Silva, Carlos Afonso, Madalena Pinto and Honorina Cidade. Isolation and Potential Biological Applications of Haloaryl Secondary Metabolites from Macroalgae. Mar. Drugs 2019, 17, 73
– Joana Araújo, Carla Fernandes, Madalena Pinto and Maria Elizabeth Tiritan. Chiral Derivatives of Xanthones with Antimicrobial Activity. Molecules 2019, 24, 314
– Daniela R. P. Loureiro, José X. Soares, Joana C. Costa, Álvaro F. Magalhães, Carlos M. G. Azevedo, Madalena M. M. Pinto and Carlos M. M. Afonso. Structures, Activities and Drug-Likeness of Anti-Infective Xanthone Derivatives Isolated from the Marine Environment: A Review. Molecules 2019, 24, 243
– Decha Kumla, Tida Dethoup, Luís Gales, José A. Pereira, Joana Freitas-Silva, Paulo M. Costa, Artur M. S. Silva, Madalena M. M. Pinto and Anake Kijjoa. Erubescensoic Acid, a New Polyketide and a Xanthonopyrone SPF-3059-26 from the Culture ofthe Marine Sponge-Associated Fungus Penicillium erubescens KUFA 0220 and Antibacterial Activity Evaluation of Some of Its Constituents. Molecules 2019, 24, 208
– João Ribeiro, Cláudia Veloso, Carla Fernandes, Maria Elizabeth Tiritan and Madalena M. M. Pinto. Carboxyxanthones: Bioactive Agents and Molecular Scaffold for Synthesis of Analogues and Derivatives. Molecules 2019, 24, 180
– Joana Moreira, Diana Ribeiro, Patrícia M. A. Silva, Nair Nazareth, Madalena Monteiro, Andreia Palmeira, Lucília Saraiva, Madalena Pinto, Hassan Bousbaa and Honorina Cidade. New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation. Molecules 2019, 24, 129
– Raquel T. Lima, Diana Sousa, Ana Sara Gomes, Nuno Mendes, Rune Matthiesen, Madalena Pedro, Franklim Marques, Madalena M. Pinto, Emília Sousa, and M. Helena Vasconcelos, The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization, Molecules 2018, 23, 3301; doi:10.3390/molecules23123301
– Barbara Silva, José A. Pereira, Sara Cravo, Ana Margarida Araújo, Carla Fernandes, Madalena M. M. Pinto, Paula Gudes de Pinho, Fernando Remião, Multi-milligram resolution and determination of absolute configuration of pentedrone and methylone enantiomers, J. Chromatography B, 2018,1100-1101, 158-164
– Eva Gil Martins, Andreia Palmeira, Helena Carmo, Emília Sousa, Agostinho Lemos, Madalena Magalhães Pinto, M.D.L. Bastos, Fernando Remião, Renata Sofia Silva, P-gp induction and activation as a potential therapeutic approach in intoxications and/or neurological diseases–in vitro and in silico studies, Toxicology Letters, 2018, October, 295:S270
– B. Silva, C. Fernandes, Madalena Magalhães Pinto, Paula Guedes de Pinho, Fernando Remião, Enantioresolution of pentedrone and methylone and in vitro dopaminergic SH-SY5Y cytotoxicity studies, Toxicology Letters, 2018, October, 295:S269
– Diana I. S. P. Resende, Patrícia Pereira-Terra, Ângela S. Inácio, Paulo Martins da Costa, Eugénia Pinto, Emília Sousa and Madalena M. M. Pinto, Lichen Xanthones as Models for New Antifungal Agents, Molecules 2018, 23, 2617
– Decha Kumla, José A. Pereira, Tida Dethoup, Luis Gales, Joana Freitas-Silva, Paulo M. Costa, Michael Lee, Artur M. S. Silva, Nazim Sekeroglu, Madalena M. M. Pinto and Anake Kijjoa, Chromone Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Penicillium erubescens KUFA0220 and Their Antibacterial Activity, Mar. Drugs 2018, 16, 289
– Diana I. S. P. Resende, Papichaya Boonpothong, Emília Sousa, Anake Kijjoa and Madalena M. M. Pinto, Chemistry of the fumiquinazolines and structurally,related alkaloids, Nat. Prod. Rep. 2018 Advance Article first published on 09 Aug 2018, http://dx.doi.org/10.1039/C8NP00043C
– Solida Long, Diana I. S. P. Resende, Anake Kijjoa, Artur M. S. Silva, André Pina, Tamara Fernández-Marcelo, M. Helena Vasconcelos, Emília Sousa and Madalena M. M. Pinto, Antitumor Activity of Quinazolinone Alkaloids Inspired by Marine Natural Products, Mar. Drugs 2018, 16, 261
– P. Brandão, J.B. Loureiro, S. Carvalho, M.H. Hamadou, S. Cravo, J. Moreira, D. Pereira, A. Palmeira, M. Pinto, L. Saraiva, H. Cidade, Targeting the MDM2-p53 protein-protein interaction with prenylchalcones: Synthesis of a small library and evaluation of potential antitumor activity, Eur J Med Chem. 2018, 156, 711-721
– Maria E. Tiritan, Carla Fernandes, Alexandra S. Maia, Madalena Pinto, Quezia B. Cass, Enantiomeric ratios: why so many notations?, J Chromatogr A. 2018 Jul 11. pii:S0021-9673(18)30923-3. doi: 10.1016/j.chroma.2018.07.039. [Epub ahead of print]
– Almeida JR, Moreira J, Pereira D, Pereira S, Antunes J, Palmeira A, Vasconcelos V, Pinto M, Correia-da-Silva M, Cidade H, Potential of synthetic chalcone derivatives to prevent marine biofouling, Sci Total Environ. 2018 Jun 20;643:98-106
– Fernando Durães, Madalena Pinto and Emília Sousa, Old Drugs as New Treatments for Neurodegenerative Diseases, Pharmaceuticals 2018, 11(2), 44
– Urbatzka, Freitas S, Palmeira A, Almeida T, Moreira J, Azevedo C, Afonso C, Correia-da-Silva M, Sousa E, Pinto M, Vasconcelos V., Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives, Eur J Med Chem. 2018 May 10;151:272-284
– A. Santos, J.X. Soares, S. Cravo, M.E. Tiritan, S. Reis, C. Afonso, C. Fernandes, M.M.M. Pinto, Lipophilicity assessement in drug discovery: Experimental and theoretical methods applied to xanthone derivatives, J. Chromatogr. B, 2018, 1072, 182–192
– A. Lopes, E. Martins, R. Silva, M.M.M. Pinto, F. Remião, E. Sousa, C. Fernandes, Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies, Molecules 2018, 23, 626
– A. R. Neves, M. Correia da Silva, P. M. A. Silva, D. Ribeiro, E. Sousa, H. Bousbaa, M. Pinto, Synthesis of New Glycosylated Flavonoids with Inhibitory Activity on Cell Growth. Molecules 2018, 23, 1093
– B.T. Martins, M. Correia da Silva, M. Pinto, H. Cidade, A. Kijjoa, Marine natural flavonoids: chemistry and biological activities. Nat Prod Res. 2018, Vol. 4, 1-13.
– Buttachon, S., Ramos, A.A., Inácio, A., Dethoup, T., Gales, L., Lee, M.; Costa, P.M., Silva, A.M.S., Sekeroglu, N., Rocha, E., Pinto, M.M.M., Pereira, J.A., Kijjoa, A. Bis-Indolyl Benzenoids, Hydroxypyrrolidine Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Aspergillus candidus KUFA0062. Marine Drugs 2018, 16, 119
– F. A. P. M. Durães, M. M. M. Pinto, M. E. S. P. Sousa. Medicinal chemistry updates on bacterial efflux pump modulators. Current Medicinal Chemistry 2018, doi.org/10.2174/0929867325666180209142612.
– F. Carvalhal, M. Correia-da-Silva, E. Sousa, M. M. M Pinto, A. Kijjoa, Sources and Biological Activities of Marine Sulfated Steroids. J. Mol. Endocrinol. 2018 doi: http://dx.doi.org/10.1530/JME-17-0252
– M. Correia-da-Silva, V. Rocha, C. Marques, C. M. Deus, A. Marques-Carvalho, P. J. Oliveira, A. Palmeira, M. Pinto, E. Sousa, J. M. Sousa Lobo, I. F. Almeida, Potential benefits of a sulfated resveratrol derivative for topical application. J. Mol. Endocrinol. 2018, 61 doi: http://dx.doi.org/10.1530/JME-18-0031
– Y. Phyo, S. Cravo, A. Palmeira, M.E. Tiritan, A. Kijjoa, M.M.M. Pinto, C. Fernandes, Enantiomeric Resolution and Docking Studies of Chiral Xanthonic Derivatives on Chirobiotic Column, Molecules 2018, 23, 142
– Carla Fernandes, Ye’ Zaw Phyo, Ana Sofia Silva, Maria Elizabeth Tiritan, Anake Kijjoa & Madalena M.M. Pinto, Chiral Stationary Phases Based on Small Molecules: An Update of the Last 17 Years, Separation & Purification Reviews, 2018, 47:2, 89-123
– Loureiro DRP, Soares J, Lopes D, Macedo T, Yordanova D, Jakobtorweihen S, Nunes C, Reis S, Pinto MMM, Afonso CMM. Accessing lipophilicity of drugs with biomimetic models: A comparative study using liposomes and micelles, Eur J Pharm Sci. 2018 Mar 30;115, 369-380
– Ye’ Zaw Phyo, João Ribeiro, Carla Fernandes, Anake Kijjoa and Madalena M. M. Pinto, Marine Natural Peptides: Determination of Absolute Configuration Using Liquid Chromatography Methods and Evaluation of Bioactivities, Molecules 2018, 23, 306
– A. Santos, J.X. Soares, S. Cravo, M.E. Tiritan, S. Reis, C. Afonso, C. Fernandes, M.M.M. Pinto, Lipophilicity assessement in drug discovery: Experimental and theoretical methods applied to xanthone derivatives, J. Chromatogr. B, 2018, 1072, 182–192.
– Jidapa Noinart, Suradet Buttachon, Tida Dethoup, Luís Gales, José A. Pereira, Ralph Urbatzka, Sara Freitas, Michael Lee, Artur M.S. Silva, Madalena M. M. Pinto, Vítor Vasconcelos, Anake Kijjoa. A New Ergosterol Analog, a New Bis-Anthraquinone and Anti-obesity Activity of Anthraquinones from the Marine Sponge-Associated Fungus Talaromyces stipitatus KUFA 0207. Mar Drugs 2017,15, 139
– War War May Zin, Suradet Buttachon, Tida Dethoup, José A. Pereira, Luís Gales, Ângela Inácio, Paulo M. Costa, Michael Lee, Nazim Sekeroglu, Artur M. S. Silva, Madalena M. M. Pinto, Anake Kijjoa. Antibacterial and antibiofilm activities of the metabolites isolated from the culture of the mangrove-derived endophytic fungus Eurotium chevalieri KUFA0006. Phytochemistry 2017,141, 86-97.
– Decha Kumla, Tin Shine Aung, Suradet Buttachon, Tida Dethoup 3,Luís Gales, José A. Pereira, Ângela Inácio, Paulo M. Costa, Michael Lee, Nazim Sekeroglu, Artur M. S. Silva, Madalena M. M. Pinto, Anake Kijjoa. A New Dihydrochromone Dimer and Other Secondary Metabolites from Cultures of the Marine Sponge-Associated Fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213. Mar. Drugs 2017, 15, 375; doi:10.3390/md15120375.
– Vilas-Boas, C.; Sousa, E.; Pinto, M. M. M; Correia-da-Silva, M. An antifouling model from the sea: a review of 25 years of zosteric acid studies. Biofouling, 2017, Nov 24:1-16. [Epub ahead of print]
– Correia-da-Silva, M.; Sousa, E.; Pinto, M.M.M; Kijjoa, A. Anticancer and cancer preventive compounds from edible marine organisms. Semin Cancer Biol. 2017 Oct;46:55-64.
– Almeida, J. R.; Correia-da-Silva, M. Sousa E.; Antunes, J.; Pinto, M.; Vasconcelos, V.; Cunha, I. Antifouling potential of Nature-inspired sulfated compounds. Scientific Reports 2017, 7, 42424 (Published online:13 February 2017).
– Lopes-Rodrigues, V.; Oliveira, A.; Correia-da-Silva, M.; Pinto M.; Lima R.T.; Sousa E.; Vasconcelos M.H. A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells. Bioorg. Med. Chem. 2017, 25 (2), 581-596.
– C. Fernandes, M.E. Tiritan, M.M.M. Pinto, Chiral Separation in Preparative Scale: A Brief Overview of Membranes as Tools for Enantiomeric Separation, Symmetry 2017, 9(206), 1-19.
– J. Ribeiro, M.E. Tiritan, M.M.M. Pinto, C. Fernandes, Chiral Stationary Phases for Liquid Chromatography Based on Chitin- and Chitosan-Derived Marine Polysaccharides, Symmetry 2017, 9(190), 1-28.
– C. Fernandes, A. Palmeira, I.I. Ramos, C. Carneiro, C. Afonso, M.E. Tiritan, H. Cidade, P.C.A.G. Pinto, M.L.M.F.S. Saraiva, S. Reis, M.M.M. Pinto, Chiral derivatives of xanthones: investigation of enantioselectivity as inhibitors of cyclooxygenases (COX-1 and COX-2) and binding interaction with human serum albumin, Pharmaceuticals, 2017, 10, 50.
– C. Fernandes, Y. Phyo, A.S. Silva, M.E. Tiritan, A. Kijjoa, M.M.M. Pinto, Chiral stationary phases based on small molecules: an update of the last seventeen years, Sep. Purif. Rev., 2017 Pages 1-35 (Published online: 11 May 2017; DOI: 10.1080/15422119.2017.1326939)
– C. Fernandes, M.E. Tiritan, S, Cravo, Y. Phyo, A. Kijjoa, A.M.S. Silva, Q.B. Cass, M.M.M. Pinto, New chiral stationary phases based on xanthone derivatives for liquid chromatography, Chirality, 2017, 29, 430–442.
– M.L. Carraro, A. Palmeira, M.E. Tiritan, C. Fernandes, M.M.M. Pinto, Resolution, determination of enantiomeric purity and chiral recognition mechanism of new xanthone derivatives on (S,S)-Whelk-O1 stationary phase. Chirality, 2017, 1–10.
– M.I. Cruz, H. Cidade, M. Pinto. Dual/multitargeted xanthone derivatives for Alzheimer’s disease: where do we stand?, Future Med Chem. 2017, 9(14), 1611-1630.
– C. Fernandes, A. Palmeira, I.I. Ramos, C. Carneiro, C. Afonso, M. E. Tiritan, H. Cidade, P.C.A.G. Pinto, M.L.M.F.S. Saraiva, S. Reis, M.M.M. Pinto. Chiral derivatives of xanthones: investigation of enantioselectivity as inhibitors of cyclooxygenases (COX-1 and COX-2) and binding interaction with human serum albumin. Pharmaceuticals, 2017, 10(50), 1-13.
– I. Cruz, P. Puthongking, S. Cravo, A. Palmeira, H. Cidade, M. Pinto, E. Sousa. Xanthone and flavone derivatives as dual agents with acetylcholinesterase inhibition and antioxidant activity as potential anti-Alzheimer agents. Journal of Chemistry, 2017, 1-16.
-. H. Cidade, V. Rocha, A. Palmeira, C. Marques, M. E. Tiritan, H. Ferreira, J. S. Lobo, I. F. Almeida, M. E. Sousa, M. Pinto, In silico and in vitro antioxidant and cytotoxicity evaluation of oxygenated xanthone derivatives, Arabian Journal of Chemistry, 2017 (Available online 25 January 2017; https://doi.org/10.1016/j.arabjc.2017.01.006)
– I. Hrynchak, E. Sousa, M. Pinto, V. M. Costa. The importance of drug metabolites synthesis: the case-study of cardiotoxic anticancer drugs. Drug Metabolism Reviews, 2017, 49 (2), 158-196.
– A. F. Ferreira, F. Ponte, R. Silva, E. Sousa, M. Pinto, A. S. Cordeiro, M. L. Bastos, F. Remião. Quantification of 1-(propan-2-ylamino)-4-propoxy-9h-thioxanthen-9-one (tx5), a newly synthetized p-glycoprotein inducer/activator, in biological samples: method development and validation. Biomedical Chromatography, 2017, 31(2), e3802
– Reis-Mendes, A.; Gomes, A.S.; Carvalho, R.A.; Carvalho, F.; Remião, F.; Pinto, M.; Bastos, M.L.; Sousa, E.; Costa, V.M. Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy. Arch Toxicol. 2016 Sep 14. [Epub ahead of print]. (DOI 10.1007/s00204-016-1839-z)
– Ana R Neves, Marta Correia-da-Silva, Emília Sousa & Madalena Pinto, Structure–activity relationship studies for multitarget antithrombotic drugs, Future Med. Chem. (Epub ahead of print), Published online: 25 November 2016, Future Medicinal Chemistry, 2016 December, 8(18), 2305-2355
– Lima RT, Sousa D, Paiva AM, Palmeira A, Barbosa J, Pedro M, Pinto MM, Sousa E, Vasconcelos MH, Modulation of Autophagy by a Thioxanthone Decreases the Viability of Melanoma Cells, Molecules 2016, Oct 10; 21(10)
– Joana Fonseca , Sandra Marques , Patrícia M. A. Silva, Pedro Brandão ,Honorina Cidade, Madalena M. Pinto and Hassan Bousbaa, Prenylated Chalcone 2 Acts as an Antimitotic Agent and Enhances the Chemosensitivity of Tumor Cells to Paclitaxel, Molecules 2016, 21, 982
– WarWar May Zin, Suradet Buttachon, Tida Dethoup, Carla Fernandes, Sara Cravo, Madalena M. M. Pinto, Luís Gales, José A. Pereira, Artur M. S. Silva, Nazim Sekeroglu and Anake Kijjoa, New Cyclotetrapeptides and a New Diketopiperzine Derivative from the Marine Sponge-Associated Fungus Neosartorya glabra KUFA 0702, Mar. Drugs 2016, 14, 136
– Chadaporn Prompanya, Tida Dethoup, Luís Gales, Michael Lee, José A. C. Pereira, Artur M. S. Silva, Madalena M. M. Pinto, Anake Kijjoa, New Polyketides and New Benzoic Acid Derivatives from the Marine Sponge-Associated Fungus Neosartorya quadricincta KUFA 0081, Mar. Drugs 2016, 14, 134;
– A. R. Neves, M. Correia-da-Silva, E. Sousa, M. Pinto. Development of multitarget inhibitors to overcome the limitations of antithrombotic therapy. Future of Medicinal Chemistry, 2016, doi:10.4155/fmc-2015-0020.
– Ana Rita Neves, Marta Correia-da-Silva, Emília Sousa, Madalena Pinto. Strategies to Overcome Heparins’ Low Oral Bioavailability. Pharmaceuticals 2016, 9, 37; doi:10.3390/ph9030037.
– Solida Long, Emília Sousa, Anake Kijjoa and Madalena M. M. Pinto, Marine Natural Products as Models to Circumvent Multidrug Resistance., Molecules 2016, 21, 892; doi:10.3390/molecules21070892.
– Bárbara Silva, Carla Fernandes, Maria Elizabeth Tiritan, Madalena M.M. Pinto, Maria João Valente, Márcia Carvalho, Paula Guedes de Pinho, Fernando Remião, Chiral enantioresolution of cathinone derivatives present in “legal highs”, and enantioselectivity evaluation on cytotoxicity of 3,4-methylenedioxypyrovalerone (MDPV), Forensic Toxicology, 2016, pp 1-14, First online: 13 June 2016, doi: 10.1007/s11419-016-0324-y
– Agostinho Lemos, Mariana Leão, Joana Soares, Andreia Palmeira, Madalena Pinto, Lucília Saraiva and Maria Emília Sousa, Medicinal Chemistry Strategies to Disrupt the p53–MDM2/MDMX Interaction, Medicinal Research Reviews, 2016, 00, No. 0, 1–56, Version of Record online: 15 JUN 2016, doi: 10.1002/med.21393
– Vanessa Lopes-Rodrigues, Ana Oliveira, Marta Correia-da-Silva, Madalena Pinto, Raquel T.Lima, Emília Sousa and M. Helena Vasconcelos, A new curcumin derivative presents more potent antitumor and anti-P-glycoprotein activity than curcumin itself, Pharmaceuticals, 2016, January, 9(15):52
– Marta Correia-da-Silva, Catarina Carvalho, Emília Sousa and Madalena Pinto, Synthesis of Innovative Anticoagulant Hybrids, Pharmaceuticals, 2016, January, 9(15):39
– Maria Emília Sousa, Ana Sara Gomes, Pedro Brandão, Carla Fernandes, Marta Correia-da-Silva, Madalena Pinto, Drug-like Properties and ADME of Xanthone Derivatives: The Antechamber of Clinical Trials, Curr Med Chem. 2016 Apr 25. [Epub ahead of print], Volume: 23, doi: 10.2174/0929867323666160425113058
– João Barbosa , Raquel T. Lima, Diana Sousa, Ana Sara Gomes, Andreia Palmeira, Hugo Seca, Kantima Choosang, Pannee Pakkong, Hassan Bousbaa, Madalena M. Pinto, Emília Sousa, M. Helena Vasconcelos, and Madalena Pedro, Screening a Small Library of Xanthones for Antitumor Activity and Identification of a Hit Compound which Induces Apoptosis, Molecules 2016, 21, 81
– Neves, A.; Sousa, E.; Pinto, M.; Correia-da-Silva, M. Potential Orally-Active Heparin-Like Compounds: Synthesis and Anticoagulant Activity. In Proceedings of the 1st Int. Electron. Conf. Med. Chem., 2–27 November; Sciforum Electronic Conference Series, Vol. 1, 2015 , A018; doi:10.3390/ecmc-1-A018
– Carla Fernandes, Letícia Carraro, Ana Sofia Silva, Cláudia Veloso, Maria Elizabeth Tiritan, Artur M.S. Silva and Madalena Pinto, Synthesis and Enantiomeric Purity Evaluation of a New Small Library of Promising Bioactive Chiral Derivatives of Xanthones Sciforum Electronic Conference Series, Vol. 1, 2015 , A021; doi:10.3390/ecmc-1-A021
– Emília Sousa, Agostinho Lemos, Ana Gomes, Sara Cravo, Madalena Pinto, Synthesis of Aminated Xanthones: Exploiting Chemical Routes to Reach for Bioactive Compounds Sciforum Electronic Conference Series, Vol. 1, 2015 , A022; doi:10.3390/ecmc-1-A022
– Kampanart Huanbutta, Maribel Teixeira, Virgínia Gonçalves, Elizabeth Tiritan, and Madalena M. M. Pinto, Development of Targeted Polymeric Nanoparticles for Acute Myeloid Leukaemia, AdvancedScience, Engineering and Medicine 2015, Vol. 7, 1–7
– Carla Fernandes, Maria Elizabeth Tiritan, Madalena M. M. Pinto, Derivados xantónicos quirais: aplicações em Química Medicinal e uma nova abordagem em Cromatografia Líquida/Chiral derivatives of xanthones: applications in Medicinal Chemistry and a new approachin Liquid Chromatography, Scientia Chromatographica 2015; 7(3):1-14
– Oliveira, a., Sousa E., Vasconcelos MH, Pinto, MM., Curcumin: a natural lead for potential new drug candidates, Curr. Med Chem. 2015 Oct 28. [Epub. ahead of print], VOLUME: 22, doi: 10.2174/0929867322666151029104611
– Mariana Leão, Joana Soares, Sara Gomes, Liliana Raimundo, Helena Ramos, Cláudia Bessa, Glória Queiroz, Sofia Domingos, Madalena Pinto, Alberto Inga, Honorina Cidade, Lucília Saraiva, Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53–MDM2 interaction, Life Sciences 2015, 142, 60–65.
– Fernanda M. F. Roleira, Elisiário J. Tavares da Silva, José A. C. Pereira, Francesco Ortuso, Stefano Alcaro, Madalena M. M. Pinto, Molecular clefts of Rebek revisited: potential application as drug carriers for the antiviral acyclovir, J Incl Phenom Macrocycl Chem, 2015, 83:203–208
– Bessa Lucinda J., Palmeira Andreia, Gomes Ana S., Vasconcelos Vitor, Sousa Emília, Pinto Madalena, and Martins da Costa Paulo. Synergistic effects between thioxanthones and oxacillin against Methicillin-Resistant Staphylococcus aureus. Microbial Drug Resistance, 2015 Aug;21(4):404-15.
– War War May Zin , Suradet Buttachon, Jamrearn Buaruang, Luís Gales, José A. Pereira, Madalena M. M. Pinto, Artur M. S. Silva and Anake Kijjoa. A New Meroditerpene and a New Tryptoquivaline Analog from the Algicolous Fungus Neosartorya takakii KUFC 7898, Mar. Drugs 2015, 13, 3776-3790.
– Chadaporn Prompanya, Carla Fernandes, Sara Cravo, Madalena M. M. Pinto, Tida Dethoup, Artur M. S. Silva, Anake Kijjoa. A New Cyclic Hexapeptide and a New Isocoumarin Derivative from the Marine Sponge-Associated Fungus Aspergillus similanensis. Mar. Drugs, 2015, 13, 1432-1450.
– A. Pedro Gonçalves, Nuno Silva, Carla Oliveira, David J. Kowbel, N. Louise Glass, Anake Kijjoa, Andreia Palmeira, Emília Sousa, Madalena Pinto, Arnaldo Videira, Transcription profiling of the Neurospora crassa response to a group of synthetic (thio)xanthones and a natural acetophenone, Genomics Data, 2015, 4, 26-32.
– Marta Correia da Silva, Honorina Cidade, Emília Sousa, Madalena Pinto, Searching for Small Molecules with Antioxidant and Anticoagulant Properties to Fight Thrombosis, Journal of Pharmaceutical Sciences and Nanotechnology, 2104, 1(1), 43-50
– Chadaporn Prompanya, Tida Dethoup, Lucinda J. Bessa, Madalena M. M. Pinto, Luís Gales, Paulo M. Costa, Artur M. S. Silva, Anake Kijjoa, New Isocoumarin Derivatives and Meroterpenoids from the Marine Sponge-Associated Fungus Neosartorya similanii, Mar. Drugs 2014, 12, 5160-5173
– Renata Silva, Andreia Palmeira, Helena Carmo, Daniel José Barbosa, Mariline Gameiro, Ana Gomes, Ana Mafalda Paiva, Emília Sousa, Madalena Pinto, Maria de Lourdes Bastos, Fernando Remião, P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents Paraquat cytotoxicity, Archives of Toxicology, 2014 (doi: 10.1007/s00204-014-1333-4, published on line 19 september)
– M.M.M. Pinto, Raquel A. P. Castanheiro and Anake Kijjoa, Xanthones from Marine-Derived Microorganisms: Isolation, Structure Elucidation, Encyclopedia of Analytical Chemistry, eds R.A. Meyers, John Wiley: Chichester. doi: 10.1002/9780470027318.a9927. Published 23 June 2014.
– Ana Paula Vale, Honorina Cidade, Madalena Pinto, M. Beatriz P.P. Oliveira, Effect of sprouting and light cycle on antioxidant activity of Brassica oleracea varieties, Food Chemistry, 2014, 165, 379–387.
– Masawang, K.; Pedro, M.; Cidade, H.; Reis, R. M.; Neves, M. P.; Corrêa, A. G.; Sudprasert, W.; Bousbaa, H.; Pinto, M. M., Evaluation of 2′,4′-dihydroxy-3,4,5-trimethoxychalcone as antimitotic agent that induces mitotic catastrophe in MCF-7 breast cancer cells, Toxicol. Lett., 2014, 229, 393-401
– Carla Fernandes, Madalena Pinto and Elizabeth Tiritan, Enantioresolution of Chiral Derivatives of Xanthones on Different Types of Liquid Chromatography Stationary Phases: A Comparative Study, Current Chromatography, 2014, 1, 139-150
– E. V. Costa, E. Sousa, K. Choosang, S. Singh, J. Rocha, R. T. Lima, P. Pakkong, S. Ahmed, M.H. Vasconcelos, C. A. Montanari, M. M. Pinto. Structure based design, synthesis, and evaluation of potential inhibitors of steroid sulfatase. Current Topics in Medicinal Chemistry,. 2014;14(8), 1033-44
– Silva R, Sousa E, Carmo H, Palmeira A, Barbosa DJ, Gameiro M, Pinto M, Bastos Mde L, Remião F., Induction and activation of P-glycoprotein by dihydroxylated xanthones protect against the cytotoxicity of the P-glycoprotein substrate paraquat, Arch Toxicol. 2014 Apr;88(4):937-51
– Clara Pereira, Vanessa Lopes-Rodrigues, Isabel Coutinho, Marta P. Neves, Raquel T. Lima, Madalena Pinto, Honorina Cidade, Maria H. Vasconcelos, Lucília Saraiva, Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays, European Journal of Pharmaceutical Sciences, 2014,54,8-16
– Fernandes, C., Masawang, K., Tiritan, M.E., Sousa, E., de Lima, V., Afonso, C., Bousbaa, H., Sudprasert, W., Pedro, M., Pinto, M.M., New chiral derivatives of xanthones: synthesis and investigation of enantioselectivity as inhibitors of growth of human tumor cell lines, Bioorganic & Medicinal Chemistry 2014, 22, 1049–1062
– M. Correia-da-Silva, E. Sousa, M.M.M. Pinto. Emerging sulfated small molecules as drugs: nature as an inspiration. Medicinal Research Reviews, 2014, 34(2), 223–279
– Cristiane M. Cazal, Kantima Choosang, Vanessa Gisele P. Severino, João B. Fernandes, Maria Fátima G. F. da Silva, Paulo C. Vieira, Maria S. J. Nascimento, Gabriela M. Almeida, M. Helena Vasconcelos, Pannee Pakkongg and Madalena M. M. Pinto, Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines, Anti-Cancer Agents in Medicinal Chemistry, 2013, 13,1582-1589
– A.M. Paiva, M. Teixeira, R. Pereira, C.M. Barbosa, E. Sousa, M. Pinto. Development and validation of a HPLC method for the quantification of a cytotoxic dihydropyranoxanthone in biodegradable nanoparticles. International Journal of Drug Delivery 2013, 5(2) ), 224-232
– Carlos M.G. Azevedo, Carlos M.M. Afonso, José X. Soares, Salette Reis, Diana Sousa, Raquel T. Lima, M. Helena Vasconcelos, Madalena Pedro, João Barbosa, Luís Gales, Madalena M.M. Pinto. Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models, European Journal of Medicinal Chemistry, 2013, 69, 798-816
– Ana Mafalda Paiva, Rita Alexandra Pinto, Maribel Teixeira, Carlos Maurício Barbosa, Raquel T. Lima, Maria Helena Vasconcelos, Emília Sousa, Madalena Pinto. Development of noncytotoxic PLGA nanoparticles to improve the effect of a new inhibitor of p53-MDM2 interaction, International Journal of Pharmaceutics, 2013, 454, 394– 402.
– Carla Fernandes, Maria Elizabeth Tiritan, Madalena Pinto, Small Molecules as Chromatographic Tools for HPLC Enantiomeric Resolution: Pirkle-type Chiral Stationary Phases Evolution, Chromatographia, 2013, 76, 871-897
– M. Leão, S. Gomes, J. Pedraza-Chaverri, N. Machado, E. Sousa, M. Pinto, A. Inga, C. Pereira, L. Saraiva. α-Mangostin and gambogic acid as potential inhibitors of p53-mdm2 interaction revealed by a yeast approach. J. Nat. Prod., 2013, 76 (4),774–778
– Carla Fernandes, Andreia Palmeira, Alexandre Santos, Maria Elizabeth Tiritan, Carlos Afonso, Madalena M. Pinto, Enantioresolution of new chiral derivatives of xanthones on (S,S)-Whelk-O1 and L-Phenylglycine stationary phases and chiral recognition mechanism by docking approach for (S,S)-Whelk-O1, Chirality, 2013 Feb;25(2):89-100
– M. Leão, C. Pereira, A. Bisio, Y. Ciribilli, A. Paiva, N. Machado, A. Palmeira, M. X. Fernandes, E. Sousa, M. Pinto, A. Inga, L. Saraiva. Discovery of a new small-molecule inhibitor of p53-MDM2 interaction using a yeast-based approach. Biochemical Pharmacology, 2013, 85 (2013) 1234–1245
– Carlos M. G.Azevedo, Carlos M. M. Afonso, Diana Sousa, Raquel T.Lima, M. Helena Vasconcelos, Madalena Pedro, JoãoBarbosa, Arlene G.Corrêa, Salette Reis, Madalena M. M.Pinto, Multidimensional optimization of promising antitumor xanthone derivatives, Bioorganic & Medicinal Chemistry, 2013, 21, 2941-2959
– Paiva, A.M., Pinto, M.M., Sousa, M.E. A century of thioxanthones: through synthesis and biological applications. Current Medicinal Chemistry, 2013, 20, 2438-2457
– R. T. Lima, H. Seca, A. Palmeira, M. X. Fernandes, F. Castro, M. Correia-da-Silva, M. S. J. Nascimento, E. Sousa, M. Pinto, M. H. Vasconcelos. Sulfated small molecules targeting EBV in Burkitt lymphoma: from an silico screening to the evidence of in vitro effect on viral episomal DNA. Chemical Biology & Drug Design. 2013, 81, 631–644
– E. Sousa, A. Palmeira, A. S. Cordeiro, B. Sarmento, D. Ferreira, R. T. Lima, M. H. Vasconcelos, M. Pinto. Bioactive xanthones with effect on P-glycoprotein and prediction of intestinal absorption. Medicinal Chemistry Research, 2013, 22(5). 2115-2123
– Palmeira A., Sousa E., Fernandes MX., Pinto MM, Vasconcelos MH, Multidrug resistance reversal effects of aminated thioxanthones and interaction with cytochrome P450 3A4. J. Pharm Pharm Sci. 2012;15(1), 31-45
– Carla Fernandes, Pedro Brandão, Alexandre Santos, Maria Elizabeth Tiritan, Carlos Afonso, Quezia B. Cass, Madalena M. Pinto, Resolution and determination of enantiomeric purity of new chiral derivatives of xanthones using polysaccharide-based stationary phases, Journal of Chromatography A, 2012 1269, 143– 153
– Kátia Roberta A. Belaz , Marina Denadai , Ana Paula Almeida , Raquel T. Lima , M. Helena Vasconcelos, M. Madalena Pinto, Quezia B. Cass, Regina V. Oliveira, Enantiomeric resolution of albendazole sulfoxide by semipreparative HPLC and in vitro study of growth inhibitory effects on human cancer cell lines, Journal of Pharmaceutical and Biomedical Analysis, 2012, Jul;66:100-8
– Andreia Palmeira, Emília Sousa, Helena Vasconcelos, Madalena Pinto, Miguel X. Fernandes, Structure and ligand-based design of P-glycoprotein inhibitors: a historical perspective, Current Pharmaceutical Design, 2012, 18(27):4197-214
– C.M.G. Azevedo, C.M.M. Pinto and M. M. M. Pinto, Routes to Xanthones: An Update on the Synthetic Approaches, Current Organic Chemistry, 2012, 16 (23), 2818-2867
– Carla Fernandes, Laura Oliveira, Maria Elizabeth Tiritan, Luís Leitao, Angelo Pozzi, José Bernardo Noronha-Matos, Paulo Correia-de-Sá, Madalena M. Pinto, Synthesis of new chiral xanthone derivatives acting as nerve conduction blockers in the rat sciatic nerve, European Journal of Medicinal Chemistry, 2012, 55, 1-11
– Marta P. Neves, Raquel T. Lima, Kanthima Choosang, Panee Pakkong, Maria de São José Nascimento, Helena Vasconcelos, Madalena Pinto, Artur M. S. Silva, Honorina Cidade. Synthesis of Natural Chalcone and its Prenyl-Analogues – Evaluation of Tumor Cell Growth Inhibitory Activity and Effects on Cell Cycle and apoptosis, Chemistry & Biodiversity, 2012, 9, 1133-1143
– Carla Fernandes ,Maria E Tiritan, Quezia Cass, Visvaldas Kairys, Miguel X Fernandes, Madalena M Pinto, Enantioseparation and Chiral Recognition Mechanism of New Chiral Derivatives of Xanthones on Macrocyclic Antibiotic Stationary Phases, Journal of Chromatography A, 2012, 1241, 60-68
– Palmeira A, Sousa E, Vasconcelos MH, Pinto MM, Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds, Curr Med Chem., 2012, 19, 1946-2025
– Andreia Palmeira, M. Helena Vasconcelos, Ana Paiva, Miguel X. Fernandes, Madalena Pinto, Emília Sousa, Dual inhibitors of P-glycoprotein and tumor cell growth: (Re)discovering thioxanthones, Biochemical Pharmacology, 2012, 83 ,57-68, on line 24th November 2011, DOI information: 10.1016/j.bcp.2011.10.004
– Marta Perro Neves, Ana Camões, Maria de São José Nascimento, Honorina Cidade, Maria Emília Sousa, Madalena Maria Magalhães Pinto, Effects of a prenyl-baicalein derivative on ER (+) MCF-7 and ER (–) MDA-MB-231 breast tumor cell lines, Medicinal Chemistry Research, 2012, 21 (10), 31-54
– Ana Mafalda Paiva, Maria Emília Sousa, Ana Camões, Maria São José Nascimento, Madalena Maria Magalhães Pinto, Prenylated Xanthones: antiproliferative effects and enhancement of the growth inhibitory action of 4-hydroxytamoxifen in estrogen receptor-positive breast cancer cell line. Medicinal Chemistry Research, 2012, 21 (5), 552-558
– Perro Neves, M., Cravo, S., Lima, R.T., Helena Vasconcelos, M., São José Nascimento, M., Silva, A.M.S., Pinto, M., Cidade, H., Corrêa, A.G., Solid-Phase Synthesis of 2´-Hydroxychalcones. Effects on Cell Growth Inhibition, Cell Cycle and Apoptosis of Human Tumor Cell Lines, Bioorganic & Medicinal Chemistry, 2012, 20, 25–33
– Orlando Pinto, João Sardinha, Pedro D. Vaz, Fátima Piedade, Maria J. Calhorda, Rudolph Abramovitch, Nair Nazareth, Madalena Pinto, Maria S. J. Nascimento, Amélia P. Rauter. Synthesis of Tetrahydronaphthalene Lignan Esters by Intramolecular Cyclization of Ethyl p-Azidophenyl-2-phenylalkanoates and Evaluation of the Growth Inhibition of Human Tumor Cell Lines. J. Med. Chem., 2011, 54, 3175-3187
– Neves MP, Cidade H, Pinto M, Silva AMS, Gales L, Damas AM, Lima RT, Vasconcelos MH, Nascimento MSJ. Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. Eur J Med Chem 2011; 46: 2562-74
– Ana Mafalda Paiva, Maria Emília Sousa, Ana Camões, Maria São José Nascimento, Madalena Maria Magalhães Pinto, Prenylated Xanthones: antiproliferative effects and enhancement of the growth inhibitory action of 4- hydroxytamoxifen in estrogen receptor-positive breast cancer cell line. Medicinal Chemistry Research, 2011, on line 27 January, DOI 10.1007/s00044-011-9562-z
– Andreia Palmeira, Freddy Rodrigues, Emília Sousa, Madalena Pinto, M. Helena Vasconcelos, Miguel X. Fernandes, New uses for old drugs: pharmacophore-based screening for the discovery of P-glycoprotein inhibitors. Chemical Biology & Drug Design, 2011, Jul; 78(1), 57-72
– Eugénia Pinto, Carlos Afonso, Serafim Duarte, Luís Vale-Silva, Elisangela Costa, Emília Sousa, Madalena Pinto, Antifungal activity of xanthones: evaluation of their effect on ergosterol biosynthesis by high-performance liquid chromatography, Chemical Biology & Drug Design, 2011, 77 (3), 212-222
– Marta Correia-da-Silva, Emília Sousa, Bárbara Duarte, Franklim Marques, Luís M. Cunha-Ribeiro, Madalena M. M. Pinto, Dual anticoagulant/antiplatelet persulfated small molecule, Eur. J. Med. Chem, 2011, 46, 2347-2358
– Correia -da-Silva M, Sousa E, Duarte B, Marques F, Carvalho F, Cunha-Ribeiro LM, Pinto MM, Polysulfated xanthones: multipathway development of a new generation of dual anticoagulant/antiplatelet agents, J. Med. Chem., 2011, 54(15):5373-84
– Marta Correia-da-Silva, Emília Sousa, Barbara Duarte, Franklim Marques, Felix Carvalho, Luís M. Cunha-Ribeiro and Madalena M. M. Pinto, Flavonoids with an Oligopolysulfated Moiety: A New Class of Anticoagulant Agents, J. Med. Chem., 2011, 54(1), 95-106
– M. Cazal, Cristiane;Choosang, Kantima;Gisele P. Severino, Vanessa;S. Soares, Marcio;Lucio F. Sarria, Andre;B. Fernandes, Joao;Fatima G.F. Silva, Maria;Cezar Vieira, Paulo;Pakkong, Pannee;M. Almeida, Gabriela;Helena Vasconcelos, M.;S.J. Nascimento, Maria;M.M. Pinto, Madalena, Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines, Anti-Cancer Agents in Medicinal Chemistry, 2010, 10, 769-776
– Ana Paula Almeida, Tida Dethoup, Narong Singburaudom, Raquel Lima, Maria Helena Vasconcelos, Madalena Pinto, Anake Kijjoa, The in vitro anticancer activity of thr crude extracto f the sponge-associated fungus Eurotium cristatum and its secondary metabolites, Journal of Natural Pharmaceuticals, 2010, 1(1), 25-29
– Andreia Palmeira, Freddy Rodrigues, Emília Sousa, Madalena Pinto, M. Helena Vasconcelos and Miguel X. Fernandes, Pharmacophore_based screening as a clue for the discovery of new P-Glycoprotein Inhibitors, Advances in Bioinformatics, IWPACBB 2010, AISC 74, 175-180
– Elisangela V. Costa, Emília Sousa, J. Rocha, Carlos A. Montanari and Madalena Pinto, Structure based design of potent inhibitors of steroid sulfatase, Advances in Bioinformatics, IWPACBB 2010, AISC 74, 151-156
– Elisangela Costa, Emília Sousa, Nair Nazareth, Maria S.J. Nascimento and Madalena M.M. Pinto, Synthesis of Xanthones and Benzophenones as Inhibitors of Tumor Cell Growth, Letters in Drug Design & Discovery, 2010, 7, 487-493
– Andreia Palmeira, Ana Paiva, Emília Sousa, H. Seca, Gabriela M. Almeida, Raquel T. Lima, Miguel X. Fernandes, Madalena Pinto, M. Helena Vasconcelos, Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone, Chemical Biology & Drug Design, 2010, 76: 43–58
– Wanida Auamcharoen, Anake Kijjoa, Angsumarn Chandrapatya, Madalena M. Pinto, Artur M.S. Silva, Waree Naengchomnong, Werner Herz, A new tetralone from Diospyros cauliflora, Biochemical Systematics and Ecology, 2009, 37, 690–692
– Luis Gales, Raquel A. P. Castanheiro, Madalena M. M. Pinto and Ana M. Damas, 1-Hydroxy-3-(3-methylbut-2-enyloxy)Xanthone. Acta Cryst., 2009, E65 (11), 2718–2719
– M. M. M. Pinto and R. A. P. Castanheiro. Synthesis of Prenylated Xanthones: An Overview, Current Organic Chemistry, 2009, 13, 1215-1240
– Castanheiro, R. A.; Silva, A. M.; Campos, N. A.; Nascimento, M. S.; Pinto, M. M. Antitumor Activity of Some Prenylated Xanthones. Pharmaceuticals 2009, 2, 33-43
– Emília Sousa, Ana Paiva, Nair Nazareth, Luis Gales, Ana M. Damas, Maria S. J. Nascimento, Madalena Pinto, Bromoalkoxyxanthones as Promising Antitumor Agents: Synthesis, Crystal Structure and Effect on Human Tumor Cell Lines, European Journal of Medicinal Chemistry, 2009, 44, 3830–3835
– Raquel A.P. Castanheiro, Madalena M.M. Pinto, Sara M.M. Cravo, Diana C.G.A. Pinto, Artur M.S. Silva, Anake Kijjoa, Improved methodologies for synthesis of prenylated xanthones by microwave irradiation and combination of heterogeneous catalysis (K10 clay) with microwave irradiation, Tetrahedron 2009, 65, 3848-3857