Scientific Publications

Books

– “Chemistry of Love and Sex”, Madalena M. M. Pinto, VHCA-Wiley-VCH, 2012 (ISBN-10 3-906390-68-3; ISBN-13 978-3-906390-68-0)

Chemistry of Love & Sex

– “Manual de Trabalhos Laboratoriais de Química Orgânica e Farmacêutica”, Madalena M. M. Pinto et col, LIDEL – edições técnicas, Lda., October 2011 (ISBN 978-972-757-750-7)

Manual de Trabalhos Laboratoriais de Química Orgânica e Farmacêutica

– Madalena M. M. Pinto, “Química do Amor e do Sexo”, LIDEL – Editors, January 2010 (ISBN 978-972-757-648-7)

Química do Amor e do Sexo

Book Chapters

– Maria Elizabeth Tiritan, Ana Rita Ribeiro, Carla Fernandes and Madalena M. M. Pinto, “Chiral pharmaceuticals”, Kirk-Othmer Encyclopedia of Chemical Technology, 1-28, Published Online: 15 SEP 2016, DOI: 10.1002/0471238961.1608011823092009.a01.pub2

– Fernandes, H. Cidade, S. Cravo, E. Sousa, M. Pinto Chapter1. Separation and Purification of Mixtures: 1.12. “Analysis of racemic and (S)-ibuprofen”, in Comprehensive Organic Chemistry Experiments for the Laboratory Classroom Royal Society of Chemistry (COCEL), Editors: Carlos A M Afonso, Nuno R Candeias, Dulce Pereira Simão, Alexandre F Trindade, Jaime A S Coelho, Bin Tan, Robert Franzén, Print publication date: 16 Dec 2016 Copyright: 2017 Print ISBN: 978-1-84973-963-4

– E. Sousa, S. Cravo, C. Fernandes, M. Pinto, Separation and Purification of Mixtures: 1.13. “Determining partition coefficients of sulfonamides by reversed-phase chromatography”, in Comprehensive Organic Chemistry Experiments for the Laboratory Classroom Royal Society of Chemistry (COCEL), Editors: Carlos A M Afonso, Nuno R Candeias, Dulce Pereira Simão, Alexandre F Trindade, Jaime A S Coelho, Bin Tan, Robert Franzén, Print publication date: 16 Dec 2016 Copyright: 2017 Print ISBN: 978-1-84973-963-4

– M.M.M. Pinto (invited author), Raquel A. P. Castanheiro and Anake Kijjoa (2014), “ Xanthones from Marine-Derived Microorganisms: Isolation, Structure Elucidation” in Handbook of Chemical and Biological Plant, edited by Kurt Hostettmann, Shilin Chen, Andrew Marston and Hermann Stuppner. Chichester, UK: John Wiley & Sons, Ltd, pp 611-632

– A. Palmeira, F. Rodrigues, E. Sousa, M. Pinto, M. H. Vasconcelos, M. X. Fernandes, “Pharmacophore-based screening as a clue for the discovery of new P-glycoprotein inhibitors”, Ed. M. P. Rocha et al., IWPACBB, AISC74, Advances in Intelligent and Soft Computing, 2010, 175-180.

– E. V. Costa, M. E. Sousa, J. Rocha, C. A. Montanari, M. M. Pinto, “Structure Based Design of Potential Inhibitors of Steroid Sulfatase”, Ed. M. P. Rocha et al., IWPACBB, AISC74, Advances in Intelligent and Soft Computing, 2010, 151-156.

– Natural Products: Chemistry, Biochemistry and Pharmacology”, NAROSA PUBLISHING HOUSE PVT. LTD., NEW DELHI, INDIA (www.narosa.com), ALPHASCIENCE INTERNATIONAL, OXFORD, UK (www.alphasci.com), ISBN: 978-81-7319-886-1, 2009

Chapter 11: Natural Prenylated Xanthones: Chemistry and Biological Activities, Madalena M. M. Pinto (invited author) and Raquel Castanheiro.

Chapter 14: Sulfated Flavonoids: Nature Playing with the Hydrophilic-Hydrophobic Balance, Maria Emilia Sousa, Marta Correia da Silva, and Madalena M.M. Pinto.

– Sousa, M. E., Correia-da-Silva, M., Pinto, M. M. M., “Sulfated Flavonoids: Nature Playing with the Hydrophilic-Hydrophobic Balance” In Natural Products: Chemistry, Biochemistry and Pharmacology, 1st ed.; Brahmachari, G., Eds.; Narosa Publishing House: New Delhi, India, 2008; pp 392-416.

– Madalena M. M. Pinto, Honorina M. M. Cidade, “Inclusion complex of Diazepam with Cyclodextrins in Solid Phase” in IUPAC: Practical Studies for Medicinal Chemistry – An integrating approach for developing countries, 2006, Eds Antonio Monge and C. Robin Ganelli, Chapter I , Exercise I.8. (http://www.iupac.org/publications/cd/medicinal_chemistry/index.html)

– Honorina Cidade, Madalena Pinto, “Analysis of Racemic Ibuprofen and (S) – Ibuprofen for the Formation of Diasterioisomeric Derivatives” in IUPAC: Practical Studies for Medicinal Chemistry – An integrating approach for developing countries, 2006, Eds Antonio Monge and C. Robin Ganelli, Chapter I.10. (http://www.iupac.org/publications/cd/medicinal_chemistry/index.html)

– Madalena M.M. Pinto, Anake Kijjoa. “Macromoléculas e Metabolitos Secundários como Indicadores de Evolução”. Em: A Evolução Cósmica e a Origem da Vida, 1985, Ed. Hernâni L. S. Maia e Joaquim J. Moura Ramos, Livraria Almedina, Coimbra.

Patents/Scientific Papers

Patents

– International patent application PCT/IB2013/050193, Inhibitors of p53-MDM2 interaction, Madalena Pinto, Lucília Saraiva, Emília Sousa, Alberto Inga, Mariana Leão, Ana Paiva, Clara Pereira, 2013/01/09.

– Identification disclosure form, in 29-07-2011, accepted by UPIN, Universidade do Porto. Portugal Patent request .Inibidores da interação p53-MDM2 in 09-01-2011.

– M. Pinto, M. E. Sousa, M. R. C Guerra, F. Marques, F. Carvalho, Portugal Patent no. 104739: Xantonas Sulfatadas E Análogos Xantónicos Glicosilados Sulfatados com Actividade Anticoagulante e Processos para a sua Preparação. Publication in Boletim da Propriedade Industrial no. 47/2011, in 09-03-2011.

– M. Pinto, M. E. Tiritan, C. Fernandes, Q. Cass, Portuguese Patent nº 104679: Fases Estacionárias Quirais baseadas em Derivados Xantónicos. Publication in Boletim da Propriedade Industrial nº 15/2011, 21-01-2011.

Scientific Papers

(last 5 years)

Accepted

Published

– Ye‛ Zaw Phyo, Sara Cravo,  Andreia Palmeira, Maria Elizabeth Tiritan, Anake Kijjoa, Madalena M. M. Pinto and Carla Fernandes, Studies of Chiral Xanthonic Derivatives on Chirobiotic Columns, Molecules 2018, 23, 142.

– A. Santos, J.X. Soares, S. Cravo, M.E. Tiritan, S. Reis, C. Afonso, C. Fernandes, M.M.M. Pinto, Lipophilicity assessement in drug discovery: Experimental and theoretical methods applied to xanthone derivatives, J. Chromatogr. B, 2018, 1072, 182–192.

– Jidapa Noinart, Suradet Buttachon, Tida Dethoup, Luís Gales, José A. Pereira, Ralph Urbatzka, Sara Freitas, Michael Lee, Artur M.S. Silva, Madalena M. M. Pinto, Vítor Vasconcelos, Anake Kijjoa. A New Ergosterol Analog, a New Bis-Anthraquinone and Anti-obesity Activity of Anthraquinones from the Marine Sponge-Associated Fungus Talaromyces stipitatus KUFA 0207. Mar Drugs 2017,15, 139

–  War War May Zin, Suradet Buttachon, Tida Dethoup, José A. Pereira, Luís Gales, Ângela Inácio, Paulo M. Costa, Michael Lee, Nazim Sekeroglu, Artur M. S. Silva, Madalena M. M. Pinto, Anake Kijjoa. Antibacterial and antibiofilm activities of the metabolites isolated from the culture of the mangrove-derived endophytic fungus Eurotium chevalieri KUFA0006. Phytochemistry 2017,141, 86-97.

– Decha Kumla, Tin Shine Aung, Suradet Buttachon, Tida Dethoup 3,Luís Gales, José A. Pereira, Ângela Inácio, Paulo M. Costa, Michael Lee, Nazim Sekeroglu, Artur M. S. Silva, Madalena M. M. Pinto, Anake Kijjoa. A New Dihydrochromone Dimer and Other Secondary Metabolites from Cultures of the Marine Sponge-Associated Fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213. Mar. Drugs 2017, 15, 375; doi:10.3390/md15120375.

– Vilas-Boas, C.; Sousa, E.; Pinto, M. M. M; Correia-da-Silva, M. An antifouling model from the sea: a review of 25 years of zosteric acid studies. Biofouling, 2017, Nov 24:1-16. [Epub ahead of print]

– Correia-da-Silva, M.; Sousa, E.; Pinto, M.M.M; Kijjoa, A. Anticancer and cancer preventive compounds from edible marine organisms. Semin Cancer Biol. 2017 Oct;46:55-64.

– Almeida, J. R.; Correia-da-Silva, M. Sousa E.; Antunes, J.; Pinto, M.; Vasconcelos, V.; Cunha, I. Antifouling potential of Nature-inspired sulfated compounds. Scientific Reports 2017, 7, 42424 (Published online:13 February 2017).

– Lopes-Rodrigues, V.; Oliveira, A.; Correia-da-Silva, M.; Pinto M.; Lima R.T.; Sousa E.; Vasconcelos M.H. A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells. Bioorg. Med. Chem. 2017, 25 (2), 581-596.

– C. Fernandes, M.E. Tiritan, M.M.M. Pinto, Chiral Separation in Preparative Scale: A Brief Overview of Membranes as Tools for Enantiomeric Separation, Symmetry 2017, 9(206), 1-19.

– J. Ribeiro, M.E. Tiritan, M.M.M. Pinto, C. Fernandes, Chiral Stationary Phases for Liquid Chromatography Based on Chitin- and Chitosan-Derived Marine Polysaccharides, Symmetry 2017, 9(190), 1-28.

– C. Fernandes, A. Palmeira, I.I. Ramos, C. Carneiro, C. Afonso, M.E. Tiritan, H. Cidade, P.C.A.G. Pinto, M.L.M.F.S. Saraiva, S. Reis, M.M.M. Pinto, Chiral derivatives of xanthones: investigation of enantioselectivity as inhibitors of cyclooxygenases (COX-1 and COX-2) and binding interaction with human serum albumin, Pharmaceuticals, 2017, 10, 50.

– C. Fernandes, Y. Phyo, A.S. Silva, M.E. Tiritan, A. Kijjoa, M.M.M. Pinto, Chiral stationary phases based on small molecules: an update of the last seventeen years, Sep. Purif. Rev., 2017 Pages 1-35 (Published online: 11 May 2017; DOI: 10.1080/15422119.2017.1326939)

– C. Fernandes, M.E. Tiritan, S, Cravo, Y. Phyo, A. Kijjoa, A.M.S. Silva, Q.B. Cass, M.M.M. Pinto, New chiral stationary phases based on xanthone derivatives for liquid chromatography, Chirality, 2017, 29, 430–442.

– M.L. Carraro, A. Palmeira, M.E. Tiritan, C. Fernandes, M.M.M. Pinto, Resolution, determination of enantiomeric purity and chiral recognition mechanism of new xanthone derivatives on (S,S)-Whelk-O1 stationary phase. Chirality, 2017, 1–10.

– M.I. Cruz, H. Cidade, M. Pinto. Dual/multitargeted xanthone derivatives for Alzheimer’s disease: where do we stand?, Future Med Chem. 2017, 9(14), 1611-1630.

– C. Fernandes, A. Palmeira, I.I. Ramos, C. Carneiro, C. Afonso, M. E. Tiritan, H. Cidade, P.C.A.G. Pinto, M.L.M.F.S. Saraiva, S. Reis, M.M.M. Pinto. Chiral derivatives of xanthones: investigation of enantioselectivity as inhibitors of cyclooxygenases (COX-1 and COX-2) and binding interaction with human serum albumin. Pharmaceuticals, 2017, 10(50), 1-13.

– I. Cruz, P. Puthongking, S. Cravo, A. Palmeira, H. Cidade, M. Pinto, E. Sousa. Xanthone and flavone derivatives as dual agents with acetylcholinesterase inhibition and antioxidant activity as potential anti-Alzheimer agents. Journal of Chemistry, 2017, 2017, 1-16.

-. H. Cidade, V. Rocha, A. Palmeira, C. Marques, M. E. Tiritan, H. Ferreira, J. S. Lobo, I. F. Almeida, M. E. Sousa, M. Pinto, In silico and in vitro antioxidant and cytotoxicity evaluation of oxygenated xanthone derivatives, Arabian Journal of Chemistry, 2017 (Available online 25 January 2017; https://doi.org/10.1016/j.arabjc.2017.01.006)

– I. Hrynchak, E. Sousa, M. Pinto, V. M. Costa. The importance of drug metabolites synthesis: the case-study of cardiotoxic anticancer drugs. Drug Metabolism Reviews, 2017, 49 (2), 158-196.

– A. F. Ferreira, F. Ponte, R. Silva, E. Sousa, M. Pinto, A. S. Cordeiro, M. L. Bastos, F. Remião. Quantification of 1-(propan-2-ylamino)-4-propoxy-9h-thioxanthen-9-one (tx5), a newly synthetized p-glycoprotein inducer/activator, in biological samples: method development and validation. Biomedical Chromatography, 2017, 31(2), e3802

– Reis-Mendes, A.; Gomes, A.S.; Carvalho, R.A.; Carvalho, F.; Remião, F.; Pinto, M.; Bastos, M.L.; Sousa, E.; Costa, V.M. Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy. Arch Toxicol. 2016 Sep 14. [Epub ahead of print]. (DOI 10.1007/s00204-016-1839-z)

– Ana R Neves, Marta Correia-da-Silva, Emília Sousa & Madalena Pinto, Structure–activity relationship studies for multitarget antithrombotic drugs, Future Med. Chem. (Epub ahead of print), Published online: 25 November 2016, Future Medicinal Chemistry, 2016 December, 8(18), 2305-2355

– Lima RT, Sousa D, Paiva AM, Palmeira A, Barbosa J, Pedro M, Pinto MM, Sousa E, Vasconcelos MH, Modulation of Autophagy by a Thioxanthone Decreases the Viability of Melanoma Cells, Molecules 2016, Oct 10; 21(10)

– Joana Fonseca , Sandra Marques , Patrícia M. A. Silva, Pedro Brandão ,Honorina Cidade, Madalena M. Pinto and Hassan Bousbaa, Prenylated Chalcone 2 Acts as an Antimitotic Agent and Enhances the Chemosensitivity of Tumor Cells to Paclitaxel, Molecules 2016, 21, 982

– WarWar May Zin, Suradet Buttachon, Tida Dethoup, Carla Fernandes, Sara Cravo, Madalena M. M. Pinto, Luís Gales, José A. Pereira, Artur M. S. Silva, Nazim Sekeroglu and Anake Kijjoa, New Cyclotetrapeptides and a New Diketopiperzine Derivative from the Marine Sponge-Associated Fungus Neosartorya glabra KUFA 0702, Mar. Drugs 2016, 14, 136

– Chadaporn Prompanya, Tida Dethoup, Luís Gales, Michael Lee, José A. C. Pereira, Artur M. S. Silva, Madalena M. M. Pinto, Anake  Kijjoa, New Polyketides and New Benzoic Acid Derivatives from the Marine Sponge-Associated Fungus Neosartorya quadricincta KUFA 0081, Mar. Drugs 2016, 14, 134;

– A. R. Neves, M. Correia-da-Silva, E. Sousa, M. Pinto. Development of multitarget inhibitors to overcome the limitations of antithrombotic therapy. Future of Medicinal Chemistry, 2016, doi:10.4155/fmc-2015-0020.

– Ana Rita Neves, Marta Correia-da-Silva, Emília Sousa, Madalena Pinto. Strategies to Overcome Heparins’ Low Oral Bioavailability. Pharmaceuticals 2016, 9, 37; doi:10.3390/ph9030037.

– Solida Long, Emília Sousa, Anake Kijjoa and Madalena M. M. Pinto, Marine Natural Products as Models to Circumvent Multidrug Resistance., Molecules 2016, 21, 892; doi:10.3390/molecules21070892.

– Bárbara Silva, Carla Fernandes, Maria Elizabeth Tiritan, Madalena M.M. Pinto, Maria João Valente, Márcia Carvalho, Paula Guedes de Pinho, Fernando Remião, Chiral enantioresolution of cathinone derivatives present in “legal highs”, and enantioselectivity evaluation on cytotoxicity of 3,4-methylenedioxypyrovalerone (MDPV), Forensic Toxicology, 2016, pp 1-14, First online: 13 June 2016, doi: 10.1007/s11419-016-0324-y

– Pereira D, Lima RT, Palmeira A, Seca H, Soares J, Gomes S, Raimundo L, Maciel C, Pinto M, Sousa E, Vasconcelos MH, Saraiva L, Cidade H, Design and synthesis of new inhibitors of p53-MDM2 interaction with a chalcone scaffold, Arabian Journal of Chemistry 2016, accepted 23 April 2016, in press, doi: 10.1016/j.arabjc.2016.04.015

– Agostinho Lemos, Mariana Leão, Joana Soares, Andreia Palmeira, Madalena Pinto, Lucília Saraiva and Maria Emília Sousa, Medicinal Chemistry Strategies to Disrupt the p53–MDM2/MDMX Interaction, Medicinal Research Reviews, 2016, 00, No. 0, 1–56,  Version of Record online: 15 JUN 2016, doi: 10.1002/med.21393

– Vanessa Lopes-Rodrigues, Ana Oliveira, Marta Correia-da-Silva, Madalena Pinto, Raquel T.Lima, Emília Sousa and M. Helena Vasconcelos, A new curcumin derivative presents more potent antitumor and anti-P-glycoprotein activity than curcumin itself, Pharmaceuticals, 2016, January, 9(15):52

– Marta Correia-da-Silva, Catarina Carvalho, Emília Sousa and Madalena Pinto, Synthesis of Innovative Anticoagulant Hybrids, Pharmaceuticals, 2016, January, 9(15):39

– Maria Emília Sousa, Ana Sara Gomes, Pedro Brandão, Carla Fernandes, Marta Correia-da-Silva, Madalena Pinto, Drug-like Properties and ADME of Xanthone Derivatives: The Antechamber of Clinical Trials, Curr Med Chem. 2016 Apr 25. [Epub ahead of print], Volume: 23, doi: 10.2174/0929867323666160425113058

– João Barbosa , Raquel T. Lima, Diana Sousa, Ana Sara Gomes, Andreia Palmeira, Hugo Seca, Kantima Choosang, Pannee Pakkong, Hassan Bousbaa, Madalena M. Pinto, Emília Sousa, M. Helena Vasconcelos, and Madalena Pedro, Screening a Small Library of Xanthones for Antitumor Activity and Identification of a Hit Compound which Induces Apoptosis, Molecules 2016, 21, 81

– Neves, A.; Sousa, E.; Pinto, M.; Correia-da-Silva, M. Potential Orally-Active Heparin-Like Compounds: Synthesis and Anticoagulant Activity. In Proceedings of the 1st Int. Electron. Conf. Med. Chem., 2–27 November; Sciforum Electronic Conference Series, Vol. 1, 2015 , A018; doi:10.3390/ecmc-1-A018

– Carla Fernandes, Letícia Carraro, Ana Sofia Silva, Cláudia Veloso, Maria Elizabeth Tiritan, Artur M.S. Silva and Madalena Pinto, Synthesis and Enantiomeric Purity Evaluation of a New Small Library of Promising Bioactive Chiral Derivatives of Xanthones Sciforum Electronic Conference Series, Vol. 1, 2015 , A021; doi:10.3390/ecmc-1-A021

– Emília Sousa, Agostinho Lemos, Ana Gomes, Sara Cravo, Madalena Pinto, Synthesis of Aminated Xanthones: Exploiting Chemical Routes to Reach for Bioactive Compounds Sciforum Electronic Conference Series, Vol. 1, 2015 , A022; doi:10.3390/ecmc-1-A022

– Carla Fernandes, Maria Elizabeth Tiritan, Madalena M. M. Pinto, Derivados xantónicos quirais: aplicações em Química Medicinal e uma nova abordagem em Cromatografia Líquida/Chiral derivatives of xanthones: applications in Medicinal Chemistry and a new approachin Liquid Chromatography, Scientia Chromatographica 2015; 7(3):1-14

– Oliveira, a., Sousa E., Vasconcelos MH, Pinto, MM., Curcumin: a natural lead for potential new drug candidates, Curr. Med Chem. 2015 Oct 28. [Epub. ahead of print], VOLUME: 22, doi: 10.2174/0929867322666151029104611

– Mariana Leão, Joana Soares, Sara Gomes, Liliana Raimundo, Helena Ramos, Cláudia Bessa, Glória Queiroz, Sofia Domingos, Madalena Pinto, Alberto Inga, Honorina Cidade, Lucília Saraiva, Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53–MDM2 interaction, Life Sciences 2015, 142, 60–65.

– Fernanda M. F. Roleira, Elisiário J. Tavares da Silva, José A. C. Pereira, Francesco Ortuso, Stefano Alcaro, Madalena M. M. Pinto, Molecular clefts of Rebek revisited: potential application as drug carriers for the antiviral acyclovir, J Incl Phenom Macrocycl Chem, 2015, 83:203–208

– Bessa Lucinda J., Palmeira Andreia, Gomes Ana S., Vasconcelos Vitor, Sousa Emília, Pinto Madalena, and Martins da Costa Paulo. Synergistic effects between thioxanthones and oxacillin against Methicillin-Resistant Staphylococcus aureus. Microbial Drug  Resistance, accepted for publication 05-02-2015. Online Ahead of Print: March 19, 2015.

– War War May Zin , Suradet Buttachon, Jamrearn Buaruang, Luís Gales, José A. Pereira, Madalena M. M. Pinto, Artur M. S. Silva and Anake Kijjoa. A New Meroditerpene and a New Tryptoquivaline Analog from the Algicolous Fungus Neosartorya takakii KUFC 7898, Mar. Drugs 2015, 13, 3776-3790.

– Chadaporn Prompanya, Carla Fernandes, Sara Cravo, Madalena M. M. Pinto, Tida Dethoup, Artur M. S. Silva, Anake Kijjoa. A New Cyclic Hexapeptide and a New Isocoumarin Derivative from the Marine Sponge-Associated Fungus Aspergillus similanensisMar. Drugs, 2015, 13, 1432-1450.

– A. Pedro Gonçalves, Nuno Silva, Carla Oliveira, David J. Kowbel, N. Louise Glass, Anake Kijjoa, Andreia Palmeira, Emília Sousa, Madalena Pinto, Arnaldo Videira, Transcription profiling of the Neurospora crassa response to a group of synthetic (thio)xanthones and a natural acetophenone, Genomics Data, 2015, 4, 26-32.

– Marta Correia da Silva, Honorina Cidade, Emília Sousa, Madalena Pinto, Searching for Small Molecules with Antioxidant and Anticoagulant Properties to Fight Thrombosis, Journal of Pharmaceutical Sciences and Nanotechnology, 2104, 1(1), 43-50

 – Chadaporn Prompanya, Tida Dethoup, Lucinda J. Bessa, Madalena M. M. Pinto, Luís Gales, Paulo M. Costa, Artur M. S. Silva, Anake Kijjoa, New Isocoumarin Derivatives and Meroterpenoids from the Marine Sponge-Associated Fungus Neosartorya similaniiMar. Drugs 2014, 12, 5160-5173

– Renata Silva, Andreia Palmeira, Helena Carmo, Daniel José Barbosa, Mariline Gameiro, Ana Gomes, Ana Mafalda Paiva, Emília Sousa, Madalena Pinto, Maria de Lourdes Bastos, Fernando Remião, P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents Paraquat cytotoxicity, Archives of Toxicology, 2014 (doi: 10.1007/s00204-014-1333-4, published on line 19 september)

– M.M.M. Pinto, Raquel A. P. Castanheiro and Anake Kijjoa,  Xanthones from Marine-Derived Microorganisms: Isolation, Structure Elucidation,  Encyclopedia of Analytical Chemistry, eds R.A. Meyers, John Wiley: Chichester. doi: 10.1002/9780470027318.a9927. Published 23 June 2014.

– Ana Paula Vale, Honorina Cidade, Madalena Pinto, M. Beatriz P.P. Oliveira, Effect of sprouting and light cycle on antioxidant activity of Brassica oleracea varieties, Food Chemistry, 2014, 165, 379–387.

– Masawang, K.; Pedro, M.; Cidade, H.; Reis, R. M.; Neves, M. P.; Corrêa, A. G.; Sudprasert, W.; Bousbaa, H.; Pinto, M. M., Evaluation of 2′,4′-dihydroxy-3,4,5-trimethoxychalcone as antimitotic agent that induces mitotic catastrophe in MCF-7 breast cancer cells, Toxicol. Lett., 2014, 229, 393-401

– Carla Fernandes, Madalena Pinto and Elizabeth Tiritan, Enantioresolution of Chiral Derivatives of Xanthones on Different Types of Liquid Chromatography Stationary Phases: A Comparative Study, Current Chromatography, 2014, 1, 139-150

– E. V. Costa, E. Sousa, K. Choosang, S. Singh, J. Rocha, R. T. Lima, P. Pakkong, S. Ahmed, M.H. Vasconcelos, C. A. Montanari, M. M. Pinto. Structure based design, synthesis, and evaluation of potential inhibitors of steroid sulfatase. Current Topics in Medicinal Chemistry,. 2014;14(8), 1033-44

– Silva R, Sousa E, Carmo H, Palmeira A, Barbosa DJ, Gameiro M, Pinto M, Bastos Mde L, Remião F., Induction and activation of P-glycoprotein by dihydroxylated xanthones protect against the cytotoxicity of the P-glycoprotein substrate paraquat, Arch Toxicol. 2014 Apr;88(4):937-51

– Clara Pereira, Vanessa Lopes-Rodrigues, Isabel Coutinho, Marta P. Neves, Raquel T. Lima, Madalena Pinto, Honorina Cidade, Maria H. Vasconcelos, Lucília Saraiva, Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays, European Journal of Pharmaceutical Sciences, 2014,54,8-16

– Fernandes, C., Masawang, K., Tiritan, M.E., Sousa, E., de Lima, V., Afonso, C., Bousbaa, H., Sudprasert, W., Pedro, M., Pinto, M.M., New chiral derivatives of xanthones: synthesis and investigation of enantioselectivity as inhibitors of growth of human tumor cell lines, Bioorganic & Medicinal Chemistry 2014, 22, 1049–1062

– M. Correia-da-Silva, E. Sousa, M.M.M. Pinto. Emerging sulfated small molecules as drugs: nature as an inspiration. Medicinal Research Reviews, 2014, 34(2), 223–279

– Cristiane M. Cazal, Kantima Choosang, Vanessa Gisele P. Severino, João B. Fernandes, Maria Fátima G. F. da Silva, Paulo C. Vieira, Maria S. J. Nascimento, Gabriela M. Almeida, M. Helena Vasconcelos, Pannee Pakkongg and Madalena M. M. Pinto, Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines, Anti-Cancer Agents in Medicinal Chemistry, 2013, 13,1582-1589

– A.M. Paiva, M. Teixeira, R. Pereira, C.M. Barbosa, E. Sousa, M. Pinto. Development and validation of a HPLC method for the quantification of a cytotoxic dihydropyranoxanthone in biodegradable nanoparticles. International Journal of Drug Delivery 2013, 5(2) ), 224-232

– Carlos M.G. Azevedo, Carlos M.M. Afonso, José X. Soares, Salette Reis, Diana Sousa, Raquel T. Lima, M. Helena Vasconcelos, Madalena Pedro, João Barbosa, Luís Gales, Madalena M.M. Pinto. Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models, European Journal of Medicinal Chemistry, 2013, 69, 798-816

– Ana Mafalda Paiva, Rita Alexandra Pinto, Maribel Teixeira, Carlos Maurício Barbosa, Raquel T. Lima, Maria Helena Vasconcelos, Emília Sousa, Madalena Pinto. Development of noncytotoxic PLGA nanoparticles to improve the effect of a new inhibitor of p53-MDM2 interaction, International Journal of Pharmaceutics, 2013, 454, 394– 402.

– Carla Fernandes, Maria Elizabeth Tiritan, Madalena Pinto, Small Molecules as Chromatographic Tools for HPLC Enantiomeric Resolution: Pirkle-type Chiral Stationary Phases Evolution, Chromatographia, 2013, 76, 871-897

– M. Leão, S. Gomes, J. Pedraza-Chaverri, N. Machado, E. Sousa, M. Pinto, A. Inga, C. Pereira, L. Saraiva. α-Mangostin and gambogic acid as potential inhibitors of p53-mdm2 interaction revealed by a yeast approach. J. Nat. Prod., 2013, 76 (4),774–778

– Carla Fernandes, Andreia Palmeira, Alexandre Santos, Maria Elizabeth Tiritan, Carlos Afonso, Madalena M. Pinto, Enantioresolution of new chiral derivatives of xanthones on (S,S)-Whelk-O1 and L-Phenylglycine stationary phases and chiral recognition mechanism by docking approach for (S,S)-Whelk-O1, Chirality, 2013 Feb;25(2):89-100

– M. Leão, C. Pereira, A. Bisio, Y. Ciribilli, A. Paiva, N. Machado, A. Palmeira, M. X. Fernandes, E. Sousa, M. Pinto, A. Inga, L. Saraiva. Discovery of a new small-molecule inhibitor of p53-MDM2 interaction using a yeast-based approach. Biochemical Pharmacology, 2013, 85 (2013) 1234–1245

– Carlos M. G.Azevedo, Carlos M. M. Afonso, Diana Sousa, Raquel T.Lima, M. Helena Vasconcelos, Madalena Pedro, JoãoBarbosa, Arlene G.Corrêa, Salette Reis, Madalena M. M.Pinto, Multidimensional optimization of promising antitumor xanthone derivatives, Bioorganic & Medicinal Chemistry, 2013, 21, 2941-2959

– Paiva, A.M., Pinto, M.M., Sousa, M.E. A century of thioxanthones: through synthesis and biological applications. Current Medicinal Chemistry, 2013, 20, 2438-2457

– R. T. Lima, H. Seca, A. Palmeira, M. X. Fernandes, F. Castro, M. Correia-da-Silva, M. S. J. Nascimento, E. Sousa, M. Pinto, M. H. Vasconcelos. Sulfated small molecules targeting EBV in Burkitt lymphoma: from an silico screening to the evidence of in vitro effect on viral episomal DNA. Chemical Biology & Drug Design. 2013, 81, 631–644

– E. Sousa, A. Palmeira, A. S. Cordeiro, B. Sarmento, D. Ferreira, R. T. Lima, M. H. Vasconcelos, M. Pinto. Bioactive xanthones with effect on P-glycoprotein and prediction of intestinal absorption. Medicinal Chemistry Research, 2013, 22(5). 2115-2123

– Palmeira A., Sousa E., Fernandes MX., Pinto MM, Vasconcelos MH,  Multidrug resistance reversal effects of aminated thioxanthones and interaction with cytochrome P450 3A4. J. Pharm Pharm Sci. 2012;15(1), 31-45

– Carla Fernandes, Pedro Brandão, Alexandre Santos, Maria Elizabeth Tiritan, Carlos Afonso, Quezia B. Cass, Madalena M. Pinto, Resolution and determination of enantiomeric purity of new chiral derivatives of xanthones using polysaccharide-based stationary phases, Journal of Chromatography A, 2012 1269, 143– 153

– Kátia Roberta A. Belaz , Marina Denadai , Ana Paula Almeida , Raquel T. Lima , M. Helena Vasconcelos, M. Madalena Pinto, Quezia B. Cass, Regina V. Oliveira, Enantiomeric resolution of albendazole sulfoxide by semipreparative HPLC and in vitro study of growth inhibitory effects on human cancer cell lines, Journal of Pharmaceutical and Biomedical Analysis, 2012, Jul;66:100-8

– Andreia Palmeira, Emília Sousa, Helena Vasconcelos, Madalena Pinto, Miguel X. Fernandes, Structure and ligand-based design of P-glycoprotein inhibitors: a historical perspective, Current Pharmaceutical Design, 2012, 18(27):4197-214

– C.M.G. Azevedo, C.M.M. Pinto and M. M. M. Pinto, Routes to Xanthones: An Update on the Synthetic Approaches, Current Organic Chemistry, 2012, 16 (23), 2818-2867

– Carla Fernandes, Laura Oliveira, Maria Elizabeth Tiritan, Luís Leitao, Angelo Pozzi, José Bernardo Noronha-Matos, Paulo Correia-de-Sá, Madalena M. Pinto, Synthesis of new chiral xanthone derivatives acting as nerve conduction blockers in the rat sciatic nerve, European Journal of Medicinal Chemistry, 2012, 55, 1-11

– Marta P. Neves, Raquel T. Lima, Kanthima Choosang, Panee Pakkong, Maria de São José Nascimento, Helena Vasconcelos, Madalena Pinto, Artur M. S. Silva, Honorina Cidade. Synthesis of Natural Chalcone and its Prenyl-Analogues – Evaluation of Tumor Cell Growth Inhibitory Activity and Effects on Cell Cycle and apoptosis, Chemistry & Biodiversity, 2012, 9, 1133-1143

– Carla Fernandes ,Maria E Tiritan, Quezia Cass, Visvaldas Kairys, Miguel X Fernandes, Madalena M Pinto Enantioseparation and Chiral Recognition Mechanism of New Chiral Derivatives of Xanthones on Macrocyclic Antibiotic Stationary Phases, Journal of Chromatography A, 2012, 1241, 60-68

– Palmeira A, Sousa E, Vasconcelos MH, Pinto MM, Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds, Curr Med Chem., 2012, 19, 1946-2025

– Andreia Palmeira, M. Helena Vasconcelos, Ana Paiva, Miguel X. Fernandes, Madalena Pinto, Emília Sousa, Dual inhibitors of P-glycoprotein and tumor cell growth: (Re)discovering thioxanthones, Biochemical Pharmacology, 2012, 83 ,57-68, on line 24th November 2011, DOI information: 10.1016/j.bcp.2011.10.004

– Marta Perro Neves, Ana Camões, Maria de São José Nascimento, Honorina Cidade, Maria Emília Sousa, Madalena Maria Magalhães Pinto, Effects of a prenyl-baicalein derivative on ER (+) MCF-7 and ER (–) MDA-MB-231 breast tumor cell lines, Medicinal Chemistry Research, 2012, 21 (10), 31-54

– Ana Mafalda Paiva, Maria Emília Sousa, Ana Camões, Maria São José Nascimento, Madalena Maria Magalhães Pinto, Prenylated Xanthones: antiproliferative effects and enhancement of the growth inhibitory action of 4-hydroxytamoxifen in estrogen receptor-positive breast cancer cell line. Medicinal Chemistry Research, 201221 (5), 552-558

– Perro Neves, M., Cravo, S., Lima, R.T., Helena Vasconcelos, M., São José Nascimento, M., Silva, A.M.S., Pinto, M., Cidade, H., Corrêa, A.G., Solid-Phase Synthesis of 2´-Hydroxychalcones. Effects on Cell Growth Inhibition, Cell Cycle and Apoptosis of Human Tumor Cell Lines, Bioorganic & Medicinal Chemistry, 2012, 20, 25–33

– Orlando Pinto, João Sardinha, Pedro D. Vaz, Fátima Piedade, Maria J. Calhorda, Rudolph Abramovitch, Nair Nazareth, Madalena Pinto, Maria S. J. Nascimento, Amélia P. Rauter. Synthesis of Tetrahydronaphthalene Lignan Esters by Intramolecular Cyclization of Ethyl p-Azidophenyl-2-phenylalkanoates and Evaluation of the Growth Inhibition of Human Tumor Cell Lines. J. Med. Chem., 2011, 54, 3175-3187

– Neves MP, Cidade H, Pinto M, Silva AMS, Gales L, Damas AM, Lima RT, Vasconcelos MH, Nascimento MSJ. Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. Eur J Med Chem 2011; 46: 2562-74

– Ana Mafalda Paiva, Maria Emília Sousa, Ana Camões, Maria São José Nascimento, Madalena Maria Magalhães Pinto, Prenylated Xanthones: antiproliferative effects and enhancement of the growth inhibitory action of 4- hydroxytamoxifen in estrogen receptor-positive breast cancer cell line. Medicinal Chemistry Research, 2011, on line 27 January, DOI 10.1007/s00044-011-9562-z

– Andreia Palmeira, Freddy Rodrigues, Emília Sousa, Madalena Pinto, M. Helena Vasconcelos, Miguel X. Fernandes, New uses for old drugs: pharmacophore-based screening for the discovery of P-glycoprotein inhibitors. Chemical Biology & Drug Design, 2011, Jul; 78(1), 57-72

– Eugénia Pinto, Carlos Afonso, Serafim Duarte, Luís Vale-Silva, Elisangela Costa, Emília Sousa, Madalena Pinto, Antifungal activity of xanthones: evaluation of their effect on ergosterol biosynthesis by high-performance liquid chromatography, Chemical Biology & Drug Design, 2011, 77 (3), 212-222

– Marta Correia-da-Silva, Emília Sousa, Bárbara Duarte, Franklim Marques, Luís M. Cunha-Ribeiro, Madalena M. M. Pinto, Dual anticoagulant/antiplatelet persulfated small molecule, Eur. J. Med. Chem, 2011, 46, 2347-2358

– Correia -da-Silva M, Sousa E, Duarte B, Marques F, Carvalho F, Cunha-Ribeiro LM, Pinto MM,  Polysulfated xanthones: multipathway development of a new generation of dual anticoagulant/antiplatelet agents,  J. Med. Chem., 2011, 54(15):5373-84

– Marta Correia-da-Silva, Emília Sousa, Barbara Duarte, Franklim Marques, Felix Carvalho, Luís M. Cunha-Ribeiro and Madalena M. M. Pinto, Flavonoids with an Oligopolysulfated Moiety: A New Class of Anticoagulant Agents, J. Med. Chem., 2011, 54(1), 95-106 (DOI: 10.1021/jm1013117). Published on Web 12/07/2010.

– M. Cazal, Cristiane;Choosang, Kantima;Gisele P. Severino, Vanessa;S. Soares, Marcio;Lucio F. Sarria, Andre;B. Fernandes, Joao;Fatima G.F. Silva, Maria;Cezar Vieira, Paulo;Pakkong, Pannee;M. Almeida, Gabriela;Helena Vasconcelos, M.;S.J. Nascimento, Maria;M.M. Pinto, Madalena, Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines,  Anti-Cancer Agents in Medicinal Chemistry, 2010, 10, 769-776

– Ana Paula Almeida, Tida Dethoup, Narong Singburaudom, Raquel Lima, Maria Helena Vasconcelos, Madalena Pinto, Anake Kijjoa, The in vitro anticancer activity of thr crude extracto f the sponge-associated fungus Eurotium cristatum and its secondary metabolites, Journal of Natural Pharmaceuticals, 2010, 1(1), 25-29

– Andreia Palmeira, Freddy Rodrigues, Emília Sousa, Madalena Pinto, M. Helena Vasconcelos and Miguel X. Fernandes, Pharmacophore_based screening as a clue for the discovery of new P-Glycoprotein Inhibitors, Advances in Bioinformatics, IWPACBB 2010, AISC 74, 175-180

– Elisangela V. Costa, Emília Sousa, J. Rocha, Carlos A. Montanari and Madalena Pinto, Structure based design of potent inhibitors of steroid sulfatase, Advances in Bioinformatics, IWPACBB 2010, AISC 74, 151-156

– Elisangela Costa, Emília Sousa, Nair Nazareth, Maria S.J. Nascimento and Madalena M.M. Pinto, Synthesis of Xanthones and Benzophenones as Inhibitors of Tumor Cell Growth, Letters in Drug Design & Discovery, 2010, 7, 487-493

– Andreia Palmeira, Ana Paiva, Emília Sousa, H. Seca, Gabriela M. Almeida, Raquel T. Lima, Miguel X. Fernandes, Madalena Pinto, M. Helena Vasconcelos, Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone, Chemical Biology & Drug Design, 2010, 76: 43–58

– Wanida Auamcharoen, Anake Kijjoa, Angsumarn Chandrapatya, Madalena M. Pinto, Artur M.S. Silva, Waree Naengchomnong, Werner Herz, A new tetralone from Diospyros cauliflora, Biochemical Systematics and Ecology, 2009, 37, 690–692

– Luis Gales, Raquel A. P. Castanheiro, Madalena M. M. Pinto and Ana M. Damas, 1-Hydroxy-3-(3-methylbut-2-enyloxy)Xanthone. Acta Cryst., 2009, E65 (11), 2718–2719

– M. M. M. Pinto and R. A. P. Castanheiro. Synthesis of Prenylated Xanthones: An Overview, Current Organic Chemistry, 2009, 13, 1215-1240

– Castanheiro, R. A.; Silva, A. M.; Campos, N. A.; Nascimento, M. S.; Pinto, M. M. Antitumor Activity of Some Prenylated Xanthones. Pharmaceuticals 2009, 2, 33-43

– Emília Sousa, Ana Paiva, Nair Nazareth, Luis Gales, Ana M. Damas, Maria S. J. Nascimento, Madalena Pinto, Bromoalkoxyxanthones as Promising  Antitumor Agents: Synthesis, Crystal Structure and Effect on Human Tumor Cell Lines, European Journal of  Medicinal Chemistry, 2009, 44, 3830–3835

– Raquel A.P. Castanheiro, Madalena M.M. Pinto, Sara M.M. Cravo, Diana C.G.A. Pinto, Artur M.S. Silva, Anake Kijjoa, Improved methodologies for synthesis of prenylated xanthones by microwave irradiation and combination of heterogeneous catalysis (K10 clay) with microwave irradiation, Tetrahedron 2009, 65, 3848-3857